北华大学学报（自然科学版）2017，Vol.18Issue(5)：649-651,3.DOI:10.11713/j.issn.1009-4822.2017.05.020
宫颈上皮内瘤变锥切术后 高危型人乳头瘤病毒感染消除情况研究
Research of HPV Infection and Clearance of Cervival Intra-Epithelial Oplasia( CIN) after Cone Resection
摘要
Abstract
Objective The aim of this study was to study the cervical conization treatment for cervical intraepithelial neoplasia ( CIN, not including carcinoma in situ ) with high-risk human papilloma virus ( HR-HPV) infection in patients with postoperative HPV infection,factors influencing the positive postoperative HR-HPV infection to negative, and investigate the curative effect of cervical circular electric lap resection ( loop electrosurgical excision procedure,LEEP) on CIN and HR-HPV infection at the same time. Method HCⅡmethod was used to detect the HR-HPV infection in 120 patients who had undergone CIN and with positive HR-HPV infection 3,6,9 and 12 months after LEEP,to observe the postoperative persistent infection and clearance, and at the same time,to evaluate and analyze the related factors affecting the postoperative persistent HR-HPV infection. Results The HR-HPV infection rate in CIN patients with the preoperative HR-HPV infection 3,6,9 and 12 months after the treatment of LEEP was 35 . 83%, 34 . 17%, 29 . 17% and 11 . 67%, respectively;thepersistent HR-HPV infection and the postoperative clearance were positively correlated with the high preoperative HR-HPV virus load (>500 RLU/CO),and not correlated with the patients' lesion levels. The postoperative persistent HPV infection rate of patients whose preoperative HR HPV-load was >500 RLU/CO was significantly higher than that of patients whose preoperative HR-HPV-load was <500 RLU/CO(P<0. 05),and the clearance of patients whose preoperative HR-HPV load was >500 RLU/CO postoperative HPV was significantly lower than that of patients whose preoperative HR HPV-load was <500 RLU/CO (P<0. 05). Conclusion LEEP is an effective method to clear the HR-HPV infection with CIN;the preoperative HR HPV load more than 500 RlU/CO company is one of the main risk factors to affect the turning of positive infection to negative infection,which is not correlated with the patient' s lesion levels,and the cervical LEEP has a certain effect in reducing the HR-HPV virus load.关键词
高危型人乳头瘤病毒/持续感染/清除率/宫颈LEEP术Key words
high-risk human papilloma virus/persistent infection/clearance/cervical LEEP operation分类
医药卫生引用本文复制引用
李沫,王孝信,宓淑芳..宫颈上皮内瘤变锥切术后 高危型人乳头瘤病毒感染消除情况研究[J].北华大学学报（自然科学版）,2017,18(5):649-651,3.基金项目
吉林省科技发展计划项目(2014180). （2014180）
