北京中医药大学学报2017，Vol.40Issue(7)：603-606,4.DOI:10.3969/j.issn.1006-2157.2017.07.013
解毒活血方对经皮冠状动脉介入术患者围术期心肌损伤的影响
Influence of Jiedu Huoxue Fang on perioperative myocardial injury in patients undergone percutaneous coronary intervention
摘要
Abstract
Objective To observe the influence of Jiedu Huoxue Fang (Detoxification and Blood-Activating Granules) on perioperative myocardial injury in patients undergone percutaneous coronary intervention (PCI).Methods The patients with angina pectoris received PCI (n =160) were randomly divided into Jiedu Huoxue Fang group (n =84) and control group (n =76).The Jiedu Huoxue Fang group was given routine treatment and Jiedu Huoxue Fang (1 dose/d) 7 d before PCI.The control group was treated with basic drugs.The levels of serum creatine kinase-M B isoenzyme (CK-MB) and cardiac troponin Ⅰ (cTn Ⅰ) were detected before and 12 h and 24 h after PCI.Results The levels of serum cTn I and CK-MB were significantly lower in Jiedu Huoxue Fang group than those in control group 12 h after PCI (P =0.003 8,P =0.027 6) and 24 h after PCI (P =0.001 2,P =0.002 7).The constituent ratio of patients with cTn Ⅰ and CK-MB increasing by 3 times more than normal value was significantly lower in Jiedu Huoxue Fang group than that in control group (P =0.008 2,P =0.007 6).Conclusion Jiedu Huoxue Fang administrated before PCI has a certain preventive effect on perioperative myocardial damage.关键词
解毒活血/经皮冠状动脉介入术/围术期心肌损伤Key words
detoxification and blood-activating/percutaneous coronary intervention/perioperative myocardial damage分类
医药卫生引用本文复制引用
王新东,祁晓霞,黄丹,张苏洁,高昕,张一炎..解毒活血方对经皮冠状动脉介入术患者围术期心肌损伤的影响[J].北京中医药大学学报,2017,40(7):603-606,4.基金项目
国家自然科学基金资助项目(No.81403386),江苏省自然科学基金资助项目(No.BK20161078),中国中医科学院江苏分院资助项目(No.JSBY1316)National Natural Science Foundation of China (No.81403386),Natural Science Foundation of Jiangsu Province (No.BK20161078),Jiangsu Branch of China Academy of Chinese Medical Sciences (No.JSBY1316) （No.81403386）
