长春中医药大学学报2017，Vol.33Issue(5)：699-702,4.DOI:10.13463/j.cnki.cczyy.2017.05.004
振腹干预对2型糖尿病大鼠血糖的调节作用与对其HPA轴影响的相关性
Regulating effect of vibration abdominal intervention on type 2 diabetic rats'blood glucose and the correlation study of the impact of the HPAAxis
摘要
Abstract
Objective Study on whether the regulation of vibration abdominal intervention on type 2 diabetes mellitus rats of blood sugar and the effects on the HPA axis is relevant or not. Methods 60 rats were randomly divided into normal control group 10 and model group 50. Make models with STZ injection combining with high sugar and high fat feeding in the model group. And pick out the rats which comply with the inclusion criteria to divide 12 into model group and 12 into treatment group. Give vibration abdominal intervention to the treatment group rats, then kill them for test. Collect and analyze the data. Results 1.After the treatment, compared with model group, the FBG level of treatment group significantly reduced (P<0.05), the adrenal index level of treatment group significantly reduced (P<0.05), the adrenal CORT concentration of treatment group significantly decreased (P<0.05) and the hypothalamus CRH concentration of treatment group significantly decreased (P<0.05). 2. Compared with normal control group, the FBG level of treatment group is still higher (P<0.05) and the adrenal index level of treatment group is still higher (P<0.05). Conclusion Vibration abdominal intervention can effectively reduce the level of FBG in type 2 diabetic rats. It means Vibration abdominal intervention has therapeutic effect on type 2 diabetic rats. The level of secretion of adrenocortical function and activity of HPA axis of the type 2 diabetic rats also reduced accordingly, which means that the regulating effect of type 2 diabetic rats glucose metabolism may be related to improve the secretion of adrenocortical function and the function of HPA axis.关键词
2型糖尿病/振腹干预/HPA轴/FBG/CORT/CRHKey words
type 2 diabetes mellitus/vibration abdominal intervention/HPA axis/FBG/CORT/CRH分类
医药卫生引用本文复制引用
王鹤,肖星蕾,赵方晓,陈幼楠,林彩霞..振腹干预对2型糖尿病大鼠血糖的调节作用与对其HPA轴影响的相关性[J].长春中医药大学学报,2017,33(5):699-702,4.基金项目
国家自然科学基金青年科学基金项目" 振腹法振频对 HPA 轴的调节作用及其对Ⅱ型糖尿病兔血糖的影响 "(81202772). （81202772）
