长春中医药大学学报2017，Vol.33Issue(5)：708-711,4.DOI:10.13463/j.cnki.cczyy.2017.05.007
4种提取工艺制备溃结康栓对溃疡性结肠炎大鼠的治疗作用
Therapeutic effect of Kuijiekang suppository with different processes on rats with ulcerative colitis induced by TNBS
摘要
Abstract
Objective To study effects of Kuijiekang suppository with four different processes on rats with ulcerative colitis induced by TNBS. Methods SD male rats were randomly divided into control group, model group, positive control group and four groups of Kuijiekang suppository with four different processes,10 rats per group. Rats model of ulcerative colitis set up by rectally administration of TNBS, except control group、model group, were given the appropriate medication to treat for 14 days. Take disease activity index, colon tissue injuries of scores, pathology, TNF-α, IL-1β, IL-4 as the detection indicator and evaluate the treatment. Results Compared with the control group, the model rats showed DAI significantly increased, the levels of TNF-α, IL-1βincreased (P<0.01), and IL-4 decreased (P<0.01). Compared with the model group, different processes and positive control group showed DAI significantly decreased (P<0.05), the levels of TNF-α, IL-1βdecreased (P<0.05), and IL-4 (P<0.05) increased. Conclusion Kuijiekang suppositories with different processes rectly have effect on the ulcerative colitis induced by TNBS, especially in the first and the fourth process. Thus, the fourth process should be taken into consideration to conduct the next research.关键词
溃结康栓/提供工艺/溃疡性结肠炎Key words
Kuijiekang suppository/process/UC分类
医药卫生引用本文复制引用
李丽霞,肖学凤,何毅,马东明,马晓伟,裴帅,夏鸿东,张懂懂,郑雪莹,黄芝娟..4种提取工艺制备溃结康栓对溃疡性结肠炎大鼠的治疗作用[J].长春中医药大学学报,2017,33(5):708-711,4.基金项目
国家自然科学基金 " 中药质量战略研究 "(81642011). （81642011）
