长春中医药大学学报2017，Vol.33Issue(5)：712-713,716,3.DOI:10.13463/j.cnki.cczyy.2017.05.008
朱砂肾脏毒性的分解研究
Study on the renal toxicity of some components in cinnabar by respective researches
摘要
Abstract
Objective To study some components relative to the concentration of mercury in plasma and the toxicity associated with cinnabar, and provide important evidence for the safety and reasonable application of cinnabar in clinical medicine and scientific preparation. Methods On the basis of partial differential principle, doing research on the components concerned to cinnabar toxicity respectively and equally by the methods of chemistry, toxicology, pharmacokinetics and cytology for finding components corresponding to cinnabar toxicity. Results The overall experimental results show that some coexisting ingredients of cinnabar may cause the changes of the chemical potential of mercury in plasma, as well as body fluid, and the permeability of the ion channel, which is conducive to gastrointestinal absorption and transportation to kidney of mercury ions. Experiments on cells indicate that almost all its components of cinnabar contribute to its toxicity. Conclusion In order to reduce the toxicity of water-handled cinnabar and make it safer, both in clinical treatment and industrial products, cinnabar processing methods should be improved by removing nitrate, chloride, magnesium ions unnecessary coexisting ions .关键词
朱砂/肾脏毒性/汞离子/炮制方法Key words
cinnabar/nephrotoxicity/mercury ion/processing method分类
医药卫生引用本文复制引用
史立,孙友,李佳,李丹阳,赵跃刚..朱砂肾脏毒性的分解研究[J].长春中医药大学学报,2017,33(5):712-713,716,3.基金项目
吉林省中医药管理局中医药科技项目 " 朱砂中与其肾脏蓄积相关成分的量效关系研究 "(2014-Q27). （2014-Q27）
