重庆医学2017，Vol.46Issue(26)：3629-3631,3.DOI:10.3969/j.issn.1671-8348.2017.26.010
炎症介质hs-CRP、IL-6和MMP-9水平与脑微出血的相关性研究
Study on correlation between levels of hs-CRP, IL-6 and MMP-9 with cerebral microbleeding
摘要
Abstract
Objective To discuss the correlation between levels of hs-CRP,IL-6 and MMP-9 with cerebral microbleeding (CMB).Methods A total of 201 of non-acute ischemic cerebrovascular were collected and performed heal MRI+ susceptibility-weighted imaging(SWI).The patients were divided into the CMB group(49 cases) and non-CMB group(152 cases) according to the SWI examination results.The clinical data were recorded in the two groups.The levels of inflammatory mediators high-sensitivity C-reactive protein (hs-CRP),interleukin-6 (IL-6) and matrix metalloproteinase-9(MMP-9) were tested.The Logistic regression analysis was used to analyze the relation between the levels of hs-CRP,IL-6 and MMP-9 with cerebral microbleeding.Results The levels of inflammatory mediators hs-CRP,IL-6 and MMP-9 in the CMB group were significantly higher than those in the non-CMB group (P＜0.05).The logisticMultivariate logistic regression analysis showed that the levels of hs-CRP,IL-6 and MMP-9[OR value(95％CI):1.745(1.342-2.270),1.223(1.018-1.533),1.284(1.082-1.423),P＜0.05)] were the risk factors of CMB after adjusting the influence of age,sex and traditional risk factors.Conclusion The levels of inflammatory mediators hs-CRP,IL-6 and MMP-9 are closely associated with CMB,which participate in CMB occurrence.关键词
脑出血/C反应蛋白质/白细胞介素6/基质金属蛋白酶9/脑微出血/危险因素/炎症介质Key words
cerebral hemorrhage/C-reactive protein/interleukin-6/matrix metalloproteinase 9/cerebral microbleeding/risk factor/inflammatory mediator分类
医药卫生引用本文复制引用
卢俏丽,李晨,贾志荣..炎症介质hs-CRP、IL-6和MMP-9水平与脑微出血的相关性研究[J].重庆医学,2017,46(26):3629-3631,3.基金项目
天津市卫生局科技基金(2013KZ021) （2013KZ021）
天津市滨海区卫生局科技项目(2013BWKY025). （2013BWKY025）
