重庆医学2017，Vol.46Issue(27)：3767-3769,3.DOI:10.3969/j.issn.1671-8348.2017.27.007
有氧运动与药物综合治疗对CAP大鼠血清免疫球蛋白和细胞因子水平的影响
Effects of comprehensive treatment of aerobic exercise and medicine on levels of serum immunoglobulins and cytokines in rats with chronic abacterial prostatitis
摘要
Abstract
Objective To observe the effects of comprehensive treatment of aerobic exercise and medicine on the levels of serum immunoglobulins and cytokines in rats with chronic abacterial prostatitis (CAP).Methods Forty healthy adult male SD rats were randomly divided into the normal control group,CAP model control group,exercise treatment group,medicine treatment group and exercise and medicine comprehensive treatment group,8 cases in each group.The CAP rat model was prepared by the injection of Xiaozhiling,and after 7 d of rat model construction,the exercise treatment group and exercise and medicine comprehensive treat ment group conducted once swimming exercise at fixed time every day,6 d per week for 4 continuous weeks;the medicine treatment group and exercise and medicine comprehensive treatment group were given Qianlieshutong Capsule aqueous solution for gavage treatment every day;the normal control group,model control group and exercise treatment group performed gastric gavage with sterile normal saline.On 14,28 d of the treatment process the rats in each group were sacrificed.The indicators such as serum immunoglobulins and cytokines in rats were detected by using ELISA.Results On 14 d,compared with the normal control group,the levels of serum IgG,IgA,IgM,TNF-α,IL-1β and IL-6 in each experimental group were increased significantly (P＜ 0.05),while which had no statistically significant difference between the exercise treatment group and model control group and between the comprehensive treatment group and medicine treatment group(P＞0.05);on 28 d,the levels of IgG,IgM,TNF-α,IL-1β and IL-6 in the exercise treatment group were significantly lower than those in the model control group(P＜0.05),the levels of IgG,IgA,TNF-α,IL-1β and IL-6 in the comprehensive treatment group were significantly lower than those in the medicine treatment group (P＜0.05),moreover were close to those in the normal control group(P＞0.05).Conclusion Aerobic exercise can reduce the levels of serum immunoglobulins and cytokines in CAP rats,and the effect is more obviousin CAP rats treated by comprehensive therapy combined with medicine.关键词
前列腺炎/有氧运动/免疫球蛋白类/细胞因子Key words
prostatitis/aerobic exercise/immunoglobulins/cytokine分类
医药卫生引用本文复制引用
孙海波,汪敏,党荣敏,秦萍,周丽琴,张玉娟..有氧运动与药物综合治疗对CAP大鼠血清免疫球蛋白和细胞因子水平的影响[J].重庆医学,2017,46(27):3767-3769,3.基金项目
贵州省卫生和计划生育委员会与黔南民族医学高等专科学校科技联合基金(gzwkj201409). （gzwkj201409）
