医学分子生物学杂志2017，Vol.14Issue(5)：287-290,294,5.DOI:10.3870/j.issn.1672-8009.2017.05.000
创伤性颅脑损伤患者IL-1β、IL-6、IL-10水平变化及临床意义
Changes of IL-1β, IL-6 and IL-10 in Patients with Traumatic Brain Injury and the Clinical Significance
周建 1沈瑞明 2郑跃芳 3马春阳 1杨堃 1王子珍1
作者信息
- 1. 海南医学院第一附属医院神经外科 海口市, 570102
- 2. 海南医学院第一附属医院风湿免疫科 海口市, 570102
- 3. 海南医学院第一附属医院检验科 海口市, 570102
- 折叠
摘要
Abstract
Objective To investigate the changes of IL-1β, IL-6 and IL-10 levels in the cere-brospinal fluid and serum of patients at different stages of traumatic brain injury ( TBI ) and the clinical significance. Methods A total of 79 cases of TBI were enrolled in the study, including 12 mild, 25 moderate, and 42 severe cases. The levels of IL-1β, IL-6 and IL-10 were measured in the cerebrospinal fluid and serum by ELISA at 1 , 2 , 3 and 7 days after TBI. Twelve healthy sub-jects were taken as control group. Results The levels of IL-1β, IL-6 and IL-10 in the cerebrospi-nal fluid and serum were significantly increased in TBI patients as compared with the control group ( P<0. 01 ) . They were much higher in severe TBI group than those in mild and moderate groups ( P<0. 01 ) . And the concentrations of pro-inflammatory and anti-inflammatory factors were signifi-cantly higher in cerebrospinal fluid than those in serum. Conclusion The levels of pro-inflammatory and anti-inflammatory factors are of clinical significance for the evaluation of the state of the illness, clinical treatment, and prognosis of TBI.关键词
创伤性颅脑损伤/IL-1β/IL-6/IL-10Key words
traumatic brain injury/IL-1β/IL-6/IL-10分类
医药卫生引用本文复制引用
周建,沈瑞明,郑跃芳,马春阳,杨堃,王子珍..创伤性颅脑损伤患者IL-1β、IL-6、IL-10水平变化及临床意义[J].医学分子生物学杂志,2017,14(5):287-290,294,5.
