医学分子生物学杂志2017，Vol.14Issue(5)：295-300,6.DOI:10.3870/j.issn.1672-8009.2017.05.000
Notch通路介导的microRNAs对肝癌干细胞的调节作用
Role of microRNA in Liver Cancer Stem Cell by Notch Signaling Pathway
摘要
Abstract
Hepatic cancer stem cells ( HSCs) are a kind of stem-cell-like cells in hepatic canc-er. HSCs play important roles in transformation, development, metastasis, drug resistance and recur-rence of hepatic cancers. MicroRNAs ( miRNAs ) are 19-22 nucleotides small non-coding RNAs, play important role in multiple biochemical processes, and regulate genesis and development of tumors through regulating key signaling pathways in cells. Besides, Notch signaling pathway is one of the most essential pathways in self-renewal, proliferation and differentiation of cancer stem cells. What are microRNAs' roles in Notch pathway? What are the effects of microRNA on self-re-newal, differentiation and carcinogenesis of HSCs by notch pathway? These are main topics of this review.关键词
肝癌干细胞/microRNA/Notch信号通路Key words
hepatic cancer stem cells/microRNA/notch pathway分类
医药卫生引用本文复制引用
魏巍,熊诗诗,郭志华,张瑞,张翔..Notch通路介导的microRNAs对肝癌干细胞的调节作用[J].医学分子生物学杂志,2017,14(5):295-300,6.基金项目
陕西省社会发展科技攻关项目 (No. 2016 SF-207)This workwas supported by a grant from the Project of Science and Tech-nology of Social Development in Shaanxi Province (No. 2016 SF-207) （No. 2016 SF-207）
