中国实用神经疾病杂志2017，Vol.20Issue(18)：4-7,4.DOI:10.3969/j.issn.1673-5110.2017.18.002
阿替普酶静脉溶栓治疗急性脑梗死的疗效及安全性
Analysis of the effect and safety of intravenous thrombolysis with alteplase in patients with acute cerebral infarc-tion
摘要
Abstract
Objective To explore the effect and safety of intravenous thrombolysis with Alteplase in patients with acute cer-ebral infarction(ACI).Methods The data of 105 patients with ACI within 4.5 hours were analyzed.The 56 patients from control group underwent routine therapy for ACI such as antiplatelet agents and Lipid-lowering agents,while the 49 patients from observa-tion group accepted intravenous thrombolysis with Alteplase before the onset of the routine therapy which will been given if there was no cerebral hemorrhage 24 hours after the intravenous thrombolysis therapy.The clinic effect of the Alteplase was assessed by the National Institutes of Health Stroke Scale(NIHSS)score,Barthel index(BI),Modified Rankin Scale(mRS)score of the two groups 90 days after the onset of treatment.The safety of Alteplase was assessed by comparing the incidence of bleeding events be-tween the two groups.Results NIHSS score:There was no statistically significant difference between the two groups in compari-son of NIHSS score before onset of treatment(P >0.05).The NIHSS score of patients from observation group was significantly lower than that from control group in 2 hours,24 hours and 7 days after onset of treatment(P <0.05).mRS score:The number of patients with good outcome is larger in observation group than in control group 90 days after treatment (P <0.05).BI score:The BI score of patients from observation group is higher than that of control group 90 days after treatment(P <0.05 ).Bleeding E-vents:Although the overall bleeding events in the observation group were higher than that in the control group (P <0.05),there was no statistically significant difference in comparison of symptomatic intracerebral hemorrhage between the two groups (P >0.05).Conclusion Within 4.5 hours of onset of ACI,intravenous thrombolysis with Alteplase has good clinical effect and is safe. So it is recommended to be used in patients with ACI.关键词
急性缺血性脑卒中/静脉溶栓/重组组织型纤溶酶原激活物Key words
Acute Cerebral Infarction/Intravenous thrombolysis/Alteplase分类
医药卫生引用本文复制引用
石智珍,白宇,赵延欣,程记伟..阿替普酶静脉溶栓治疗急性脑梗死的疗效及安全性[J].中国实用神经疾病杂志,2017,20(18):4-7,4.基金项目
上海中医药大学附属普陀医院重点学科建设项目(2016102A) （2016102A）
上海中医药大学第五批后备业务专家培养计划资助项目(B-X-80) （B-X-80）
