中国实用神经疾病杂志2017，Vol.20Issue(18)：32-34,3.DOI:10.3969/j.issn.1673-5110.2017.18.010
鼠神经生长因子治疗视神经挫伤的疗效观察
The clinical effect analysis of mouse nerve growth injection on optic nerve contusion
摘要
Abstract
Objective To investigate the clinical effect and safety of mouse nerve growth injection on optic nerve contusion and its impact on visual evoked potential (VEP).Methods The subjects of this study were selected from 68 cases (68 eyes)of pa-tients with optic nerve contusion admitted in our hospital from June 2014 to December 2016,who were randomly divided into the observation group and the control group,each with 34 cases (34 eyes).The control group was treated with glucocorticoids and vi-tamins.The observation group was administered with mouse nerve growth factor 30 μg+2 mL sterile water injected into the mus-cle,in addition to what was given to the control group.It was given to the observation group once daily for 6 weeks.Patients'vi-sion,central vision field grayscale,latency and amplitude of VEP and adverse reactions before and after treatment between the two groups were compared.Results After treatment,the overall effective rate of the observation group was 91.18%,which had signif-icant difference from 70.59% of the control group (P <0.05).After treatment,the vision of all cases from both groups got im-proved,their central vision field grayscale declined,their latency of VEP got shortened,and the amplitudes of VEP increased.The difference was significant ((P <0.05 ).And the improvement in the observation group was significantly better than the control group (P <0.05).There were no adverse events during treatment (P >0.05).Conclusion In treatment of optic nerve contusion, mouse nerve growth injection has a significant curative effect.It's helpful for patients to restore their vision and VEP improve-ment,safe and worth clinical application.关键词
注射用鼠神经生长因子/视神经挫伤/视觉诱发电位Key words
Mouse nerve growth injection/Optic nerve contusion/Visual evoked potential分类
医药卫生引用本文复制引用
吴睿..鼠神经生长因子治疗视神经挫伤的疗效观察[J].中国实用神经疾病杂志,2017,20(18):32-34,3.基金项目
河南省2013年度卫生科研规划项目(编号:2013WS0179) （编号:2013WS0179）
