摘要
Abstract
Objective To analyze the correlation between leukoaraiosis caused by cerebral small vessel disease and cognitive im-pairment.Methods Sixty patients with cerebral small vessel disease complicated with leukoaraiosis in our hospital from October 2015 to October 2016 were enrolled as research group;another 60 cases of healthy medical staff without neurological and psychiat-ric disorders were enrolled as control group.Patients in research group received brain MR scan and divided into Ⅰ degree (mild) subgroup of 20 cases,Ⅱ degree (moderate)subgroup of 20 cases and Ⅲ degree (severe)subgroup of 20 cases according to the leukoaraiosis grading scale.The cognitive function was evaluated by concise mental state scale and Montreal cognitive scale,the correlation between leukoaraiosis and cognitive impairment was analyzed.Results The influential factors of leukoaraiosis were age and microbleeds (P <0.05),but there was no significant difference between the education time,the history of hypertension,diabe-tes mellitus and hyperlipidemia (P >0.05).The concise mental state scale scores showed that,the score of the patients in the sub-group was 20.5±4.1,which was not significantly different from 22.5±4.5 of the control group (t =1.395,P >0.05).The scores of the patients with subgroup Ⅱ and Ⅲ were 16.5±3.5 and 16.0±3.3,respectively,which were significantly lower than 22.5± 4.5 of the control group (P <0.05).The detailed score of the Montreal cognitive scale showed that,the visual spatial and execu-tive abilities,attention,linguistic competence,abstraction ability,naming ability,delayed memory and orientation score were signifi-cantly lower in the study group than in the control group (P <0.05).Conclusion Leukoaraiosis caused by cerebral small vessel disease is closely correlated with cognitive impairment.We can take early examination of cognitive impairment according to the pa-tients leukoaraiosis.关键词
脑小血管病/脑白质疏松/认知功能障碍Key words
Cerebral small blood vessel disease/Leukoaraiosis/Cognitive dysfunction分类
医药卫生
