中国实用神经疾病杂志2017，Vol.20Issue(18)：46-49,4.DOI:10.3969/j.issn.1673-5110.2017.18.014
XRCC1在胶质瘤中的表达及意义
The expression and significance of XRCC1 in gliomas tissues
刘岩 1付旭东1
作者信息
- 1. 郑州大学第五附属医院神经外科,河南 郑州 450052
- 折叠
摘要
Abstract
Objective To analyze the expression of XRCC1 in glioma and adjacent tissues and normal tissues.Methods 50 samples of brain gliomas removed from surgery in department of neurosurgery of The Fifth Affiliated Hospital of Zhengzhou Uni-versity from July 2015 to March 2016 were collected.All samples had been diagnosed,verified and graded according to pathological types by the pathology department of our hospital.Besides,10 samples of normal brain tissues resected from patients with cerebral hemorrhage caused by hypertension were collected as control group.The XRCC1 expression in the two groups was detected and the positive rate and correlation between XRCC1 in brain gliomas of different levels and the relation of XRCC1 with age and gender were analyzed.Result The difference between the XRCC1 positive rate of low-degree malignant group of glioma (Ⅰ-Ⅱ)and that of high-degree malignant group of glioma (Ⅲ-Ⅳ)had no statistical significance (P >0.05).Among 10 samples of normal brain tissues,the total positive expression rate of XRCC1 was 0%.According to statistical analysis,there was significant difference be-tween the expression of XRCC1 in normal brain tissues and glioma tissues (P <0.05).Among the 50 samples of glioma tissues, after statistical analysis,there was no difference between the expression of XRCC1 in the patients'ages and genders (P >0.05). Conclusion The expression of XRCC1 in gliomas is significantly higher than that in normal brain tissues;the expression of XRCC1's positive rate has no correlation with the malignant degrees of gliomas.关键词
脑胶质瘤/XRCC1/免疫组化/表达意义Key words
Brain gliomas/XRCC1/Immunohistochemistry/Expressive meaning分类
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刘岩,付旭东..XRCC1在胶质瘤中的表达及意义[J].中国实用神经疾病杂志,2017,20(18):46-49,4.
