中国实用神经疾病杂志2017，Vol.20Issue(18)：53-55,3.DOI:10.3969/j.issn.1673-5110.2017.18.016
氟西汀对急性脑梗死患者急性期神经功能及血清炎性介质的影响
Effects of fluoxetine on acute neurological function and serum inflammatory mediators in patients with acute cer-ebral infarction
王小亚1
作者信息
- 1. 平顶山市第二人民医院神经内科,河南 平顶山 467000
- 折叠
摘要
Abstract
Objective To explore effects of fluoxetine on acute neurological function and serum inflammatory mediators in patients with acute cerebral infarction.Methods 128 cases with ACI in our hospital from October 2014 to October 2016 were se-lected as research objectives and divided them into two groups randomly with 64 cases in each group.We provided routine treat-ment to two groups and provided fluoxetine to observation group additionally.Use scandinavian stroke scale (MESSS)to evaluate neurological impairment in patients,use enzyme-linked immunosorbent to investigate serum inflammatory mediators level including interleukin-6 (IL-6),interleukin-8 (IL-8)and tumor necrosis factor α (TNF-α)and compare two groups'mediators before and after treatment.Results After receiving treatment for 1 week and 3 weeks,observation group's MESSS score were sig-nificantly lower than that in control group (P <0.05).The levels of IL-6,IL-8 and TNF-αof two groups decreased after receiving treatment for 2 days and 8 days,and these factors in the observation group were significantly lower than that in control group (P <0.05).Conclusion Fluoxetine can alleviate the degree of neurological damage and reduce the level of serum inflammatory mediators in patients with ACI.It is worthy to be clinical promoted.关键词
氟西汀/急性脑梗死/神经功能/血清炎性介质Key words
Fluoxetine/Acute cerebral infarction/Neurological function/Serum inflammatory mediators分类
医药卫生引用本文复制引用
王小亚..氟西汀对急性脑梗死患者急性期神经功能及血清炎性介质的影响[J].中国实用神经疾病杂志,2017,20(18):53-55,3.
