吉林中医药2017，Vol.37Issue(9)：916-920,5.DOI:10.13463/j.cnki.jlzyy.2017.09.015
降糖通脉片联合二甲双胍对2型糖尿病患者球后动脉血流动力学及氧化应激指标的影响
Influence of ball Hemodynamics and oxidative stress indicators of type 2 diabetes with Jiangtang Tongmai combined with metformin
摘要
Abstract
Objective To observe the influence of ball Hemodynamics and oxidative stress indicators of type 2 diabetes with Jiangtang Tongmai combined with metformin. Methods 81 patients diagnosed with type 2 diabetes were randomly divided into observation group (n=40) and control group (n=41). The control group was received by metformin, while whe observation group were treated with metformin tablets combined with Jiangtang Tongmai. Before and after treatment, the changes of arterial hemodynamics and oxidative stress indexes and the adverse reactions in the course of treatment were detected. Results 1)After treatment, the maximum systolic blood flow velocity in the observation group central retinal artery (PSV), end diastolic minimum velocity (EDV) and resistance index (RI) index were (8.86±0.11)cm/s, (2.62±0.10)cm/s, (0.95±0.06), all better than the control group (8.71±0.09)cm/s, (2.47±0.07)cm/s, (0.87±0.05), and the difference was significant (P＜0.05). 2) After treatment observation group ciliary artery PSV, EDV and RI were (18.81±0.61)cm/s, (4.89±0.08)cm/s, (0.99±0.07), all better than the control group (17.95 ±0.56)cm/s, (4.78±0.0.06)cm/s, (0.89±0.06), and the difference was significant (P＜0.05). 3)After treatment, the observation group oxidative stress glutathione peroxidase (GSH-PX), superoxide dismutase (SOD) were (27.81±0.93)umol/L, (269.42±16.92)IU/mL, which are better than the control group (26.58±0.81)umol/L, (245.92±15.13)IU/mL, and the difference was significant (P＜0.05). 4)Observation group oxidative stress reactive oxygen species (ROS)and malondialdehyde (MDA) were (594.62±15.43)IU/mL, (48.76±3.15)nmol/mL, all better than the control group (625.90±21.04)IU/mL, (55.49±4.92)nmol/mL, and the difference was significant (P＜0.05). 5)The total adverse reaction rate in the observation group was 17.50％, witch was higher than that in the control group (12.20％). But the difference was not statistically significant (P＞0.05). Conclusion metformin alone and Jiangtang Tongmai combined with metformin can improve type 2 diabetes ball Hemodynamics indexes, optimizing and oxidative stress parameters in patients, but the combination better.关键词
降糖通脉片/二甲双胍/2型糖尿病/球后血流动力学/氧化应激反应Key words
Jiangtang Tongmai tablets/metformin/type 2 diabetes/the ball artery/oxidative stress分类
医药卫生引用本文复制引用
李伟,郭伟,周密,高明松,涂明利..降糖通脉片联合二甲双胍对2型糖尿病患者球后动脉血流动力学及氧化应激指标的影响[J].吉林中医药,2017,37(9):916-920,5.基金项目
湖北省自然科学基金项目(2013CFB468). （2013CFB468）
