军事医学2017，Vol.41Issue(7)：611-614,4.DOI:10.7644/j.issn.1674-9960.2017.07.013
血液透析联合血液灌流治疗对清除维持性血液透析患者体内蛋白结合类毒素的长期临床研究
Long-term clinical study of effects of hemodialysis combined with hemoperfusion on clearance of protein-bound uremic toxins in maintenance hemodialysis patients
欧志强 1伦立德 2李新伦 2李检 3窦桂芳3
作者信息
- 1. 河北北方学院研究生院,河北张家口 075000
- 2. 空军总医院肾病科,北京 100142
- 3. 军事医学科学院野战输血研究所药代动力学实验室,北京 100850
- 折叠
摘要
Abstract
Objective To observe the effects of long-term hemodialysis(HD) combined with hemoperfusion(HP) on the levels of protein-bound uremic toxins (PBUTs) in maintenance hemodialysis (MHD) patients.Methods Forty-six patients with MHD were selected and divided into HD +HP group and HD group .HD+HP group ( n=22 ) was treated with low-flux HD twice a week and HD combined with HP once a week ,while HD group(n=24) was treated with low-flux HD three times a week.The follow-up lasted 36 weeks.The pre-dialysis concentration of PBUTs was measured at week 12, 24, 36 and baseline.PBUTs included hippuric acid (HA), indoxyl sulphate (IS)and p-cresyl sulphate (PCS).High performance liquid chromatography-tandem mass spectrometry ( HPLC-MS/MS) was used for determination .Results After 36 weeks of follow-up, the concentration of the three toxins in the HD +HP group was lower than that in the HD group during the study.At the end of the study, the reduction rates of HA, IS and PCS were 33.5%,12.8% and 24.2%, respectively, in HD+HP group.The three toxins in HD group increased by 2.3%,21.8%and 2.8%.The clearance rate of HA, PCS and IS in the HP+HD group was higher than in HD group (P<0.05).Conclusion Long-term HD combined with HP can more effectively remove PBUTs , and keep them at a lower level .关键词
蛋白结合类毒素/血液灌流/血液透析/高效液相色谱-串联质谱Key words
protein-bound uremic toxins/hemoperfusion/hemodialysis/high-performance liquid chromatography/tandem mass spectrometry分类
医药卫生引用本文复制引用
欧志强,伦立德,李新伦,李检,窦桂芳..血液透析联合血液灌流治疗对清除维持性血液透析患者体内蛋白结合类毒素的长期临床研究[J].军事医学,2017,41(7):611-614,4.
