检验医学与临床2017，Vol.14Issue(19)：2815-2817,3.DOI:10.3969/j.issn.1672-9455.2017.19.001
射血分数保留心力衰竭住院患者LVEF与NT-proBNP的相关性研究
Study on correlation between LVEF and NT-proBNP level in hospitalized patients with heart failure and preserved ejection fraction
摘要
Abstract
Objective To investigate the correlation between the left ventricular ejection fraction(LVEF)and N terminal brain natriuretic peptide precursor(NT-proBNP)level in the inpatients with heart failure(HF)and preserved ejection fraction(HFpEF). Methods A total of 339 hospitalized patients with heart failure were collected and grouped according to the Heart Failure Guide-lines of the European Society of Cardiology.The NT-proBNP level,biochemical indicators and cardiac Doppler ultrasonic parameters were detected.Then the correlation analysis of detection results was performed.Results In the patients with HFpEF,LVEF had no correlation with NT-proBNP,the difference was not statistically significant(P >0.05).But in all patients with HF,the NT-proBNP level was significantly increased with LVEF decrease,the difference was statistically significant (r = - 0.470,P < 0.001 ). Conclusion In the patients with HF,the NT-proBNP level is significantly decreased with LVEF decrease.But in HFpEF patients, LVEF and HFpEF have no this rule.Therefore the severity and prognosis of HFpEF patients can not be simply judged by LVEF or NT-proBNP level in clinic.关键词
射血分数保留心力衰竭/左心室射血分数/氮末端脑钠尿肽前体Key words
heart failure with preserved ejection fraction/left ventricular ejection fraction/N-terminal pro-brain natriuretic peptide引用本文复制引用
任明岗,王西辉,李鑫,于军,常盼,王建榜,吴娟,张学策,张静,严昌林..射血分数保留心力衰竭住院患者LVEF与NT-proBNP的相关性研究[J].检验医学与临床,2017,14(19):2815-2817,3.基金项目
国家自然科学基金资助项目(81270329,81470438) （81270329,81470438）
陕西省教育厅科研计划资助项目(16JF023,16JK1667) （16JF023,16JK1667）
西安医学院重点实验室开放资助项目(2016ZDKF09). （2016ZDKF09）
