检验医学与临床2017，Vol.14Issue(19)：2824-2826,2829,4.DOI:10.3969/j.issn.1672-9455.2017.19.004
螺内酯与贝前列素钠联合治疗糖尿病肾病的疗效分析
Efficacy analysis of spironolactone combined with Beraprost sodium in treatment of diabetic nephropathy
摘要
Abstract
Objective To study the efficacy of spironolactone combined with Beraprost sodium in the treatment of diabetic ne-phropathy and their influence on microalbumin(mALB),homeostasis model assessment-insulin resistance index(HOMA-IR)and C-reactive protein(CRP).Methods One hundred and ninety-eight patients with diabetic nephropathy in the hospital from June 2014 to December 2015 were selected as the research subjects.Their clinical medical records were retrospectively analyzed.According to different treatment methods,all patients were divided into the observation group (n=98)and control group (n=100).The control group was treated with spironolactone,while the observation group was treated with spironolactone combined with Beraprost sodi-um.The clinical efficacies were observed and compared between the two groups.Results (1)The clinical efficacy of the observa-tion group was significantly higher than that of the control group,the difference was statistically significant(89.80% vs .67.00%, P <0.05);(2)mALB,HOMA-IR,CRP,24 h urinary protein,serum creatinine(Scr),blood urea nitrogen(BUN),SBP,DBP,whole blood specific viscosity,plasma specific viscosity and whole blood specific reduction viscosity before treatment had no statistically significant differences between the two groups (P >0.05);the above indexes after treatment in the observation group were signifi-cantly lower than those in the control group,the differences were statistically significant(P < 0.05 ).Conclusion Spironolactone combined with Beraprost sodium for treating diabetic nephropathy has significant effect in reducing blood pressure,blood lipids level and blood viscosity,and improving the renal function,therefore this treatment method is worth further promotion and use in clinic.关键词
螺内酯/贝前列素钠/糖尿病肾病Key words
spironolactone/Beraprost sodium/diabetic nephropathy/treatment efficacy引用本文复制引用
陈岚,杨婉花..螺内酯与贝前列素钠联合治疗糖尿病肾病的疗效分析[J].检验医学与临床,2017,14(19):2824-2826,2829,4.基金项目
2016 年上海市临床药学重点专科建设项目(沪卫药政 2016-7). （沪卫药政 2016-7）
