检验医学与临床2017，Vol.14Issue(19)：2853-2855,3.DOI:10.3969/j.issn.1672-9455.2017.19.014
维生素D受体基因多态性与藏族儿童结核病易感性研究
Study on vitamin D receptor gene polymorphisms and pulmonary tuberculosis susceptibility among Tibetan children in Qinghai-Tibetan plateau
摘要
Abstract
Objective To study the correlation between vitamin D receptor(VDR)gene FokⅠ and BsmⅠ polymorphisms with pulmonary tuberculosis (PTB)susceptibility among Tibetan children in Qinghai-Tibetan plateau.Methods One hundred and sixty-two Tibetan children cases of PTB in the Qinghai Provinicial Women and Children's Hospital during 2013 to 2015 were selected as the cases group and 167 healthy Tibetan children with mycobacterial contact history as the healthy control group.The VDR gene FokⅠ and BsmⅠ in the two groups were detected by PCR-RFLP.The association between two kinds of polymorphisms with PTB susceptibility were analyzed by adopting PCR-RFLP.Then the distribution results of different samples were performed the statisti-cal analysis for conducting the relationship between the two kinds of polymorphisisms and PTB susceptibility of Tibetan children. Results The genotype frequencies of FF,Ff and ff in the cases group were higher than those in the control group,the difference was statistically significant(P <0.05,OR:2.692,95%CI :1.349-5.373).The genotype BB,Bb and bb had no statistically signifi-cant difference between the cases group and control group(P >0.05,OR:1.00995%CI :0.560 - 1.816 ).Conclusion The VDR FokⅠ gene polymorphism is corrrelated with the PTB susceptibility among Tibetan children in Qinghai-Tibetan plateau,its geno-type ff might be an onset risk factor.But the BsmⅠ polymorphism has no relationship with PTB onset.关键词
维生素D受体/青藏高原/藏族儿童/结核Key words
vitamin D receptor/Qinghai-Tibetan plateau/Tibetan children/tuberculosis引用本文复制引用
张弢,张艳虹,朱国龙,李天如,王淼舟..维生素D受体基因多态性与藏族儿童结核病易感性研究[J].检验医学与临床,2017,14(19):2853-2855,3.基金项目
青海省科技计划资助项目(2013-Z-740). （2013-Z-740）
