检验医学与临床2017，Vol.14Issue(19)：2864-2865,2868,3.DOI:10.3969/j.issn.1672-9455.2017.19.018
潮汕地区人群CYP2C9基因多态性研究
Study of CYP2C9 gene polymorphism among population in Chaoshan area
胡婧 1肖曈曈 1潘美晨 1张悄忻 1程碧珍 1蔡应木1
作者信息
- 1. 汕头大学医学院第一附属医院检验科,广东汕头 515041
- 折叠
摘要
Abstract
Objective To investigate the distribution situation of CYP2C9 gene polymorphism among population in Chaoshan ar-ea,and gene type distribution and gene mutation frequency.Methods The sequencing method was used to detect CYP2C9 ?2 and CYP2C9?3 gene polymorphism in 204 local healthy volunteers.Results Among detected 204 volunteers,184 cases of CYP2C9 ?1/?1,19 cases of CYP2C9 ? 1/? 3,and only 1 case of CYP2C9 ? 3/? 3 were detected,no case of CYP2C9 ? 1/? 2,CYP2C9 ?2/?2 and CYP2C9?2/?3 mutation was detected.The CYP2C9 ?3 mutation rate had statistical difference between male and fe-male (P <0.05).Conclusion The polymorphism distribution of CYP2C9 gene is related to gender in Chaoshan area,and the per-sonalized medication according to genotype difference is conducive to clinical therapy.关键词
CYP2C9/基因多态性/序列分析Key words
CYP2C9/gene polymorphism/sequence analysis引用本文复制引用
胡婧,肖曈曈,潘美晨,张悄忻,程碧珍,蔡应木..潮汕地区人群CYP2C9基因多态性研究[J].检验医学与临床,2017,14(19):2864-2865,2868,3.
