上海针灸杂志2017，Vol.36Issue(9)：1111-1115,5.DOI:10.13460/j.issn.1005-0957.2017.09.1111
电针治疗膝骨关节炎临床研究
Clinical Study on Electroacupuncture for Knee Osteoarthritis
摘要
Abstract
Objective To observe the clinical efficacy of electroacupuncture (EA) in treating knee osteoarthritis (KOA).Method Sixty KOA patients were randomized into a treatment group and a control group by using random number table, 30 cases each. The control group was intervened by oral administration of Celecoxib capsules, while the treatment group was given EA, 14 d as a treatment course. The changes of relevant cytokines [apelin, tumor necrosis factor (TNF)-α, TNF soluble receptor (TNFsR)-Ⅰ, TNFsR-Ⅱ, interleukin (IL)-1β, and IL-6] in serum of the two groups were observed.Result The intra-group comparisons of the total score, and the scores of pain, stiffness and dysfunction of the Western Ontario and McMaster Universities (WOMAC) osteoarthritis index showed significant differences in both groups (P<0.05); there were significant between-group differences in comparing the total score, and the scores of pain, stiffness and dysfunction of the WOMAC index after the treatment (P<0.05). The Visual Analogue Scale (VAS) scores were changed significantly after the intervention in both groups (P<0.05); there was nosignificant difference in comparing the VAS score between the two groups after the treatment (P>0.05). The levels of IL-6, TNF-α and TNFsR-Ⅰ were significantly changed after the treatment in both groups (P<0.05); the level of IL-1β was markedly changed after the intervention in the control group (P<0.05); there was a significant change in the level of apelin after the intervention in the treatment group (P<0.05), and there was a significant difference in comparing the level of apelin between the two groups after the treatment (P<0.05).Conclusion EA can produce a satisfactory efficacy in treating KOA; it can significantly improve the symptoms and signs, and mitigate pain and symptoms through regulating the expressions of cytokines.关键词
针刺疗法/电针/骨关节炎,膝关节/细胞因子/WOMAC/VASKey words
Acupuncture therapy/Electroacupuncture/Osteoarthritis,Knee/Cytokine/WOMAC/VAS分类
医药卫生引用本文复制引用
具紫勇,王颖,陈昌乐,崔花顺,丁佳燕,王珂..电针治疗膝骨关节炎临床研究[J].上海针灸杂志,2017,36(9):1111-1115,5.基金项目
国家自然科学基金(81202767) （81202767）
上海市自然科学基金(15ZR1441300) （15ZR1441300）
上海市卫生局中医药科研基金项目(2012QL016A （）
2014JP030A) （）
国家体育总局气功中心科研课题(QG2016045) （QG2016045）
上海市中医药事业发展三年行动计划项目(ZY3-CCCX-2-1003) （ZY3-CCCX-2-1003）
