摘要
Abstract
The effects of reaction conditions including reaction time,temperature,pressure, ethanol and water content on one-pot synthesis of 2 ,6-dimethylquinoline (2 ,6-DiMeQ) from 4-ni-trotoluene and ethanol over Cu-Pd/γ-Al2O3 catalyst were studied.The conversion of p-nitrotolu-ene and the selectivity of 2,6-dimethylquinoline reached 100% and 68.97% respectively,after 12 h under the optimal reaction conditions of T=453 K,p=3.5 MPa,18 g of p-nitrotoluene,60 mL of ethanol,30 mL of water and 1 g of Cu-Pd/γ-Al2O3 .With iron promoted Cu-Pd/γ-Al2O3 catalyst,the selectivity of 2,6-dimethylquinoline was increased to 71.08%.The reaction realizes the coupling of multi-reactions including hydrogen transfer hydrogenation from ethanol to 4-nitrotoluene,aldol-condensation of aldehyde,Michael-addition of 4-methylaniline and unsaturated aldehydes,dehydration-cyclization and dehydrogenation.Therefore,such one-pot process signifi-cantly simplifies the procedure for 2,6-dimethylquinoline production,as well as solves the prob-lems of product separation and catalyst recovery,thus providing a new path for synthesis of quin-oline and its derivatives.关键词
喹啉/一锅法/多相催化/双金属催化剂/Al2O3催化剂/金属助剂/2,6-二甲基喹啉/Cu-Pd/γ-Al2O3Key words
quinoline/one-pot synthesis/heterogeneous catalyses/bimetallic catalyst/Al2O3 catalyst/metal promoter/2/6-dimethylquinoline/Cu-Pd/γ-Al2O3分类
化学化工
