医药导报2017，Vol.36Issue(10)：1190-1193,4.DOI:10.3870/j.issn.1004-0781.2017.10.025
重症监护病房患者美罗培南治疗药物监测队列研究
Cohort Study of Therapeutic Drug Monitoring on Meropenem in Intensive Care Unit Patients
摘要
Abstract
Objective To evaluate whether individualized dosage regimen based on therapeutic drug monitoring (TDM) is beneficial for improving the rate of pharmacokinetics/pharmacodynamics (PK/PD) reaching the standard and anti-infection efficacy. Methods Totally, 36 cases in the intensive care unit ( ICU ) of Nanjing Drum Tower Hospital using meropenem during January 2015 to December 2015 were collected, and divided into intervention group and control group. Results On the fourth day of administration, meropenem concentration in intervention group was significantly higher than that of the control group (22.5 μgmL-1 and 17.5 μgmL-1, respectively, P=0.007).With minimal inhibitory concentration (Cmin)>8 μgmL-1 serving as target, the rate of reaching the standard was both 22. 2% on day 2, 100. 0% and 72. 2% on day 4 in intervention group and control group, respectively (P=0.015). With minimal inhibitory concentration (Cmin) >32 μgmL-1 serving as target, the rate of reaching the standard was both 0 on day 2, 38. 9% and 5. 5% on day 4 in intervention group and control group, respectively (P=0.015). The clinical curative rate of the intervention group and control group was 83.3% and 72.2%, respectively (P=0.437), and the failure rate was 16.7% and 27.8%, respectively.Bacteria clearance rate was 88.9%and 55.5% in the intervention group and control group, respectively(P<0.05). Conclusion Individualized dosage regimen based on TDM in ICU patients is beneficial to improving the rate of PK/PD reaching the standard and anti-infection efficacy.关键词
美罗培南/治疗药物监测/药动学/药效学/最低抑菌浓度Key words
Meropenem/Therapeutic drug monitoring/Pharmacokinetics/pharmacodynamics/Minimal inhibitory concentration分类
医药卫生引用本文复制引用
金路,罗雪梅,张海霞,葛卫红..重症监护病房患者美罗培南治疗药物监测队列研究[J].医药导报,2017,36(10):1190-1193,4.基金项目
中央高校基本科研业务费专项资金资助项目(021414380082) （021414380082）
