中风与神经疾病杂志2017，Vol.34Issue(9)：792-796,5.
血管内皮生长因子Rs3025039基因多态性与脑卒中关联研究的Meta分析
Correlation between vascular endothelial growth factor gene Rs3025039 polymorphism and stroke:a meta-analysis
摘要
Abstract
Objective To evaluate the relationship between vascular endothelial growth factor ( VEGF ) gene Rs3025039 polymorphism and stroke by a meta-analysis .Methods All eligible published literatures regarding to the VEGF Rs3025039 polymorphism and stroke were retrieved from searching PubMed ,EMbase,Wed of Science ,The Cochrane Library,Elsevier,China National Knowledge Infrastructure ,China Biology Medicine disc ,WanFang Data,VIP Database for Chinese Technical Periodicals ,Sciencepaper Online .The methodological quality of the included studies was evaluated and meta-analysis was performed with Rev Man 5.3 software.Results A total of 11 case-control studies with 3597 stroke cases and 2748 controls,of which 10 were Asian,were recruited into this study .The meta-analysis revealed that the combined odds ratio (OR) for T allele was 1.25(1.15～1.37) times higher than C allele;The OR for homozygous TT and CC was 1. 38(1.08～1.76);The ORs of dominant model and recessive model were 1.26(1.03～1.54) and 1.33(1.06～1.68) re-spectively;All above P values were less than 0.05.The OR for heterozygous CT and CC was 1.12(0.86～1.46),P=0.40.Under the dominant model,the OR of infarction group (including 7 studies),hemorrhage group (including 3 stud-ies),large artery atherosclerosis group (including 3 studies),small artery occlusion group (including 4 studies) was 1.31 (1.01～1.70),1.09(0.68～1.73),1.36(0.74～2.51),1.25(0.90～1.73),respectively.However,all P values were more than 0.05.Conclusion The VEGF T polymorphism may be a risk factor for stroke ,especially in Chinese and other Asians.关键词
血管内皮生长因子/基因多态性/脑卒中/Meta分析Key words
VEGF/Polymorphism/Stroke/Meta-analysis分类
医药卫生引用本文复制引用
徐炳东,詹锐,麦鸿成,陈丹霞,周锐意,徐安定,张玉生..血管内皮生长因子Rs3025039基因多态性与脑卒中关联研究的Meta分析[J].中风与神经疾病杂志,2017,34(9):792-796,5.基金项目
国家自然科学基金(No.81171084) （No.81171084）
广东省自然科学基金(No.2014A030313384) （No.2014A030313384）
广东省医学科研基金(No.A2014381) （No.A2014381）
广州市科技计划(No.2014Y2-00505、201508020004) （No.2014Y2-00505、201508020004）
