中国感染控制杂志2017，Vol.16Issue(10)：925-930,6.DOI:10.3969/j.issn.1671-9638.2017.10.007
贵州省接受抗病毒治疗艾滋病患者的生存因素分析
Survival factors of AIDS patients receiving antiretroviral therapy in Guizhou Province
摘要
Abstract
Objective To explore the survival time and its influencing factors of patients in Guizhou Province after they received antiretroviral therapy(ART)for treating human immunodeficiency virus (HIV)infection and acquired immunodeficiency syndrome (AIDS).Methods A retrospective cohort analysis was conducted to analyze survival time of AIDS patients who received ART in Guizhou Province in 2005-2016,life table method was used to calculate the survival probability,Cox proportional hazards regression model was used to analyze the influencing factors of survival time.Results A total of 15921 patients were included in the study,the median age at the beginning of therapy was(42.13±14.40)years old,58.61% of patients were married/housemate.The length of ART follow-up was (median[P 25 -P 75 ]:15.96[6.00 - 33.00])months.9.77% of the follow-up cases died,59.29% of the deaths occurred within 12 months of initiation of treatment;survival rates in the first,fifth,and tenth year were 93.00%,82.00%,and 74.00% respectively.Cox proportional hazards regression model analysis showed that fe-male patients were 0.58 times more likely to die than male patients(95% CI :0.49-0.68);the risk of death in-creased with increase of ages;the higher the baseline CD4+ T lymphocyte count,the lower the risk of death;the risk of death in patients without symptoms or signs before therapy was 0.70 times than those with symptoms or signs(95% CI :0.60-0.81).Conclusion The antiviral therapy of AIDS patients in Guizhou Province is generally well,patients with high risk factors for death should be paid high attention,it is suggested that medical level and service quality should be improved when patients are treated.关键词
艾滋病/人类免疫缺陷病毒/艾滋病患者/抗病毒治疗/生存分析Key words
acquired immunodeficiency syndrome/human immunodeficiency virus/AIDS patient/antiretroviral therapy/survival analysis分类
医药卫生引用本文复制引用
陈洋,刘跃辉,安邦权,申莉梅,李豫,李进岚,黄璐,安竹,李志坚,鲁俊端,张晓萍..贵州省接受抗病毒治疗艾滋病患者的生存因素分析[J].中国感染控制杂志,2017,16(10):925-930,6.基金项目
贵州省科技计划项目(黔科合 SY[2013]3052 号) （黔科合 SY[2013]3052 号）
