中国感染控制杂志2017，Vol.16Issue(10)：931-935,5.DOI:10.3969/j.issn.1671-9638.2017.10.008
负压引流联合纳米银敷料促进感染切口愈合的实验及临床研究
Experimental and clinical study on negative pressure suction combined with nano-silver dressing for promoting healing of infected incision
摘要
Abstract
Objective To evaluate the advantage of homemade negative pressure device combined with nano-silver dressing for promoting the healing of infected incision in rats,and explore its clinical curative effect.Methods In-fected incision model rats were randomly divided into conventional treatment group,and simple pressure suction group,pressure suction combined with silver ion dressing group.The healing time and healing area of rats in each group after treatment were evaluated,immunohistochemical and fluorescent quantitative analysis of inflammatory factors in incisional wound tissue were performed.Three methods were applied to patients with surgical site infec-tion(SSI),granulation coverage time,granulation recovery time,and incision healing time of three groups of pa-tients were compared.Results Immunohistochemistry and its IOD value,the relative mRNA expression levels of TNF-α,IL-2,and IL-8 in rat wound tissue treated with pressure suction combined with silver ion dressing were all inferior to conventional treatment group and simple negative pressure suction group,difference was statistically sig-nificant (P < 0.05);in clinical application,wound healing time,postoperative C-reactive protein level,and pain as-sessment scores in patients treated with pressure suction combined with silver ion dressing were all superior to con-ventional treatment group and simple negative pressure suction group,difference were all statistically significant (all P < 0.05).Conclusion Compared with conventional treatment method,pressure suction with silver ions dressing treatment can more effectively control SSI,reduce local inflammation of incision,and promote incision healing.关键词
自制负压装置/纳米银敷料/感染切口/炎性细胞因子Key words
homemade negative pressure device/nano-silver dressing/infected incision/inflammatory cytokine分类
医药卫生引用本文复制引用
成沛玉,邹惠美,王蓉,许静,尹娇,鄢碧玙,杨剑英..负压引流联合纳米银敷料促进感染切口愈合的实验及临床研究[J].中国感染控制杂志,2017,16(10):931-935,5.基金项目
湖南省湘潭市科技计划项目(S2015S0013) （S2015S0013）
