摘要
Abstract
AIM:To explore the effect of gimeracil capsules combined with radiotherapy on breast cancer,and on tumor marker,human epidermal growth factor receptor-2 (HER-2) and level of midkine (MK).METHODS:Sixty-four breast cancer patients were selected by random number table method from January 2010 to May 2016 in our hospital,sixty-two cases in each group.The control group was treated with three-dimensional conformal radiotherapy;the study group was treated with three-dimensional conformal radiotherapy and gimeracil capsule;the therapy continued for 2 courses of treatment.Clinical efficacy and adverse reaction incidence rate were compared between two groups;tumor markers (CEA,CA125,CA153) and changes of MK,HER-2 level were analyzed.RESULTS:The effective rate (50％) and tumor control rate (81.25％) of the study group were higher than those of the control group (25％,53.13％),the difference were statistically significant (P ＜ 0.05);Before treatment,no significant difference of CEA,CA125,CA153 was observed between groups (P ＞ 0.05),while all the indexes decreased after treatment,and the study group presented more significant change than the control group (P ＜0.05);Before treatment,no significant difference of HER-2 and MK level was observed between groups (P ＞ 0.05),while all the indexes decreased after treatment,and the study group presented more significant change than the control group (P ＜0.05).Both groups presented no Ⅳ degrees of adverse reactions,and compared with control group (31.24％,37.51％,34.37％),the incidence of leucopenia,diarrhea,nausea and vomiting (34.38％,34.38％,37.51％) of the study group presented no statistically significance (P ＞ 0.05).CONCLUSION:Gimeracil capsules combined with radiotherapy exhibited remarkable effect on breast cancer,and on the serum tumor markers,human epidermal growth factor receptor-2 and midkine expression level.With high safety,it is worthy of promotion.关键词
替吉奥胶囊/放疗/乳腺癌/肿瘤标志物/人类表皮生长因子受体-2Key words
gimeracil capsules/radiotherapy/breast cancer/tumor marker/human epidermal growth factor receptor-2分类
医药卫生
