中国临床药理学与治疗学2017，Vol.22Issue(8)：910-916,7.
瘦素及其受体基因多态性与高血压相关性的Meta分析
Association of leptin and leptin receptor gene polymorphisms with hypertension: a Meta-analysis
摘要
Abstract
AIM:To evaluate the association between leptin gene and leptin receptor gene polymorphisms with hypertension.METHODS:CNKI,Wanfang database,Chongqing VIP network,Pubmed database and EMBASE database were researched.The data on the relationship between leptin/its receptor gene and hypertension were extracted and evaluated by software STATA11.0.RESULTS:Twenty-one studies involving 4 736 patients and 3 096 healthy people were included.The mcta-analysis showed the Ⅱ/Ⅰ polymorphism of LEP gene was associated with hypertension in recessive genetic model and additive genetic model (recessive genetic model:OR =2.16,95％ CI =1.08-4.31,P =0.029,additive genetic model:OR =2.27,95％ CI =1.08-4.79,P =0.031);the Gln223Arg polymorphism of LEPR gene was associated with hypertension in dominant model and allelic model (dominant model:OR =1.55,95％CI =1.14-2.11,P=0.005;allelic model:OR =1.36,95％ CI =1.09-1.71,P =0.007).No statistically significant correlation was found between the Lysl09Arg polymorphism of LEPR gene and hypertension (dominant model:OR =0.87,95％ CI =0.67-1.14,P =0.307,recessive genetic model:OR =0.91,95％ CI =0.70-1.20,P =0.099,additive genetic model:OR =0.92,95％CI =0.70-1.21,P =0.071,allelic model:OR =1.04,95％ CI =0.80-1.35,P =0.830).CONCLUSION:There is no significant correlation between Lys109Arg polymorphism of LEPR gene and hypertension,but the Ⅱ/Ⅰ polymorphism of LEP gene and Gln223Arg polymorphism of LEPR gene are associated with hypertension.关键词
高血压/瘦素/瘦素受体/基因多态性/Meta分析Key words
hypertension/leptin/leptin receptor/gene polymorphism/Meta-analysis分类
医药卫生引用本文复制引用
张晓宇,方正美,姚应水..瘦素及其受体基因多态性与高血压相关性的Meta分析[J].中国临床药理学与治疗学,2017,22(8):910-916,7.基金项目
国家自然科学基金资助项目(81541071 （）
81072367) （）
