中国临床药理学与治疗学2017，Vol.22Issue(8)：927-932,6.
Syndecan-1在结直肠癌中的表达与EGFR表达、K-Ras突变及化疗疗效相关性分析
Relationship of Syndecan-1 and EGFR expression, K-Ras gene mutations and response to FOLFOX in advanced colorectal carcinoma
摘要
Abstract
AIM:To investigate the relationship of Syndecan-1 and EGFR expression,K-Ras gene mutations and response to FOLFOX in advanced colorectal carcinoma.METHODS:160 surgical specimens of advanced colorectal carcinoma from patients consecutively treated between June 2009 and December 2014 at our hospital were collected.Immunohistochemistry method was used to screen for Syndecan-1 expression.The relationship between Syndecan-1 expression and various clinicopathological parameters,molecular markers,curative effect of FOLFOX was analyzed.RESULTS:Syndecan-1 expression was identified in the cancer cells of 41 (25.6％) colorectal cancer cases,epidermal growth factor receptor expression in 111 (69.4％) colorectal cancer cases.The expression of syndecan-1 was statistically correlated with the expression of epidermal growth factor receptor (P ＜ 0.05).However,it was not significantly correlated with K-Ras mutation (P ＞ 0.05).Patients with over-expressed Syndecan-1 exhibited better efficacy on FOLFOX solution than patients presented negative Syndecan-1 expression (56.1％ vs.40.3％,P ＜0.05);Patients with over-expressed Syndecan-1 also presented longer median time to progress (8.8 month vs.7.2 month,P ＜ 0.05).CONCLUSION:The expression of Syndecan-1 is referential for evaluating the progress and the prognosis of colorectal cancer.And the expression of Syndecan-1 is statistically correlated with curative effect of FOLFOX regimens.关键词
结直肠癌/Syndecan-1/表皮生长因子受体/K-Ras/化疗疗效Key words
colorectal carcinoma/Syndecan-1/EGFR/K-RAS/curative effect of chemotherapy分类
医药卫生引用本文复制引用
原少斐,朱林佳,郑维锷,梁美珍..Syndecan-1在结直肠癌中的表达与EGFR表达、K-Ras突变及化疗疗效相关性分析[J].中国临床药理学与治疗学,2017,22(8):927-932,6.基金项目
浙江省科技计划项目(2016L10320) （2016L10320）
