中国临床药理学与治疗学2017，Vol.22Issue(8)：948-954,7.
表面修饰白蛋白纳米粒在肿瘤靶向治疗中的研究进展
Research progress of surface modified albumin nanoparticles in tumor targeting therapy
摘要
Abstract
At present,most drugs for clinical cancer therapy are non-selective,with the inhibition of tumor cell proliferation,they also have significant side effects on normal tissues,thereby improving the tumor-selective capacity,reducing their gathering in non-targeted areas are the keys to enhance the effectiveness of anti-cancer drugs.As drug carriers,albumin nanoparticles exhibit various outstanding biological properties,and now have been used in targeted delivery systems.The paper reviews the albumin g tumor aggregation features,the latest researches in the targeted therapy of tumor and clinical applications when they are modified with RGD peptides,monoclonal antibodies,folic acid,hyaluronic acid,transferrin and other targeted material,in order to provide advices for developing safe and effective tumor targeting drugs.关键词
白蛋白纳米粒/靶向修饰/肿瘤治疗/应用Key words
albumin nanoparticles/targeted modification/tumor therapy/applications分类
医药卫生引用本文复制引用
许丽华,徐肖阳,徐骏军,俞文英..表面修饰白蛋白纳米粒在肿瘤靶向治疗中的研究进展[J].中国临床药理学与治疗学,2017,22(8):948-954,7.基金项目
浙江省中医药科技计划项目(2016ZA130) （2016ZA130）
