中国临床药理学杂志2017，Vol.33Issue(15)：1464-1468,5.DOI:10.13699/j.cnki.1001-6821.2017.15.025
牛蒡子不同炒制品中的成分与含量及其对动物的抗炎活性对比研究
Study on component content and anti-inflammatory activity of different processed products of Great Burdock Achene in animals
摘要
Abstract
Objective To study processing mechanism of Great Burdock Achene(GBA).Methods The contents of arctinin,arctigenin were determined by HPLC.Total lignanoids was determined by UV.The fatty oil was determined by ether extractum.Comparison between varying degrees stir-frying GBA were made.And to make a comparison about their anti-inflammatory activity by tests of mice auricle swelling caused by xylene and mice foot swelling caused by carrageenin.Results Arctiin content was changed from 6.03％ to 1.07％,arctigenin content was changed from 0.32％ to 2.61％ with adding of time and temperature in process of stir-frying.And a new absorption peak appeared at 27 min.But the content of total lignanoids did not change obviously.Unripe burdock and stir-fried burdock canall inhibit mice auricle swelling caused by xylene and mice foot swelling caused by carrageenin varying degrees.And the stir-fried burdock in 200 ℃ (auricle tumidness inhibition ratio was 36.0％,foot tumidness inhibition ratio was 16.9％) and 250 ℃ (auricle tumidness inhibition ratio was 36.8％,foot tumidness inhibition ratio was 18.7％) were surpassed unripe burdock and stir-fried burdock in 100 ℃ (auricle tumidness inhibition ratio was 29.8％,foot tumidness inhibition ratio was 12.4％) and 250 ℃ (auricle tumidness inhibition ratio was 32.7％,foot tumidness inhibition ratio was 13.0％) on anti-inflammatory activity.Conclusion About every 200 g GBA should be stir-frying for 4-6 min in 200-250 ℃.The processing mechanism of stir-frying GBA was to make apart of arctiin break down into arctigenin,and burst the shuck to make fatty oil dissolved easily.关键词
牛蒡子/炒制/牛蒡苷/牛蒡苷元/总木脂素/醚浸出物/抗炎Key words
Great Burdock Achene/stir-frying/arctinin/arctigenin/total lignans/ether extractum/anti-inflammatory分类
医药卫生引用本文复制引用
邵晶,文喜艳,王兰霞,王志旺,郭玫..牛蒡子不同炒制品中的成分与含量及其对动物的抗炎活性对比研究[J].中国临床药理学杂志,2017,33(15):1464-1468,5.基金项目
甘肃省青年科技计划基金资助项目(1107RJYA019) （1107RJYA019）
甘肃省中药药理与毒理学重点实验室自主研究基金资助项目(ZDSYS-ZZKJ-2013(B)-003) （ZDSYS-ZZKJ-2013(B）
