中国临床药理学杂志2017，Vol.33Issue(15)：1491-1493,1502,4.DOI:10.13699/j.cnki.1001-6821.2017.15.034
布瓦西坦的药理作用及临床评价
Pharmacological effects and clinical evaluation of brivaracetam
洪雪姣 1赵淑娟 1王漪檬 1秦玉花 1赵红卫1
作者信息
摘要
Abstract
Brivaracetam is a selective,high-affinity synaptic vesicle protein 2A (SV2A) ligand,which was approved for the adjunctive treatment of 16 years of age and older patients with partial seizures.Brivaracetam is a structural analogues of levetiracetam,but has a 15-30 fold increased affinity for SV2A compared with levetiracetam.It works quickly through the blood-brain barrier and has less interaction with other drugs.This paper summarizes the research advances of brivaracetam on the pharmacodynamics,pharmacokinetics,drug interaction,toxicology,clinical research,security and use in specific population.The results can provide useful information for the treatment of antiepileptic therapy.关键词
布瓦西坦/抗癫痫药/药效学/药代动力学Key words
brivaracetam/antiepileptic drug/pharmacokinetics/pharmacodynamics分类
医药卫生引用本文复制引用
洪雪姣,赵淑娟,王漪檬,秦玉花,赵红卫..布瓦西坦的药理作用及临床评价[J].中国临床药理学杂志,2017,33(15):1491-1493,1502,4.
