中国临床药理学杂志2017，Vol.33Issue(16)：1531-1533,3.DOI:10.13699/j.cnki.1001-6821.2017.16.004
碳酸镧咀嚼片联合醋酸钙片治疗维持性血液透析患者高磷血症的临床研究
Clinical trial of lanthanum carbonate chewable tablets combination with calcium acetate tablets in the maintenace treatment of hemodialysis patients with hyperphosphatemia
摘要
Abstract
Objective To evaluate the clinical efficacy of lanthanum carbonate combined with calcium acetate in the treatment of hemodialysis patients with hyperphosphatemia.Methods A total of 70 cases with hemodialysis were randomly divided into treatment group (n =35) and control group(n =35).Patients in control group were orally given calcium acetate 667 mg,tid.Patients in treatment group were orally given lantha num carbonate 250 mg,tid on the basis of control group.All patientswere treated for 12 weeks.The clinical effect and levels of phosphorus,cal-cium and intact parathyroid hormone (iPTH) in two groups were observed.Also,the adverse drug reactions in two groups were observed.Results After treatment,the total efficacy rates in treatment group and control group were 91.43％ (32/35),71.43％ (25/35),with significant difference (P ＜ 0.05).Mter treatment,the levels of phosphorus,calcium and iPTH in treatment group were (1.73 ±0.16)mmol · L-1,(2.25 ±0.15) mmol · L-1,(189.60 ±68.49) pg · mL-1,had significant difference with those in control group,which were (1.88 ± 0.29)mmol · L-1,(2.45 ±0.19)mmol · L-1,(217.83 ±64.O0)pg · mL-1 (P ＜ 0.05).There were 2 cases of nausea and vomiting in treatment group,with the incidence of 5.71％ (2/35 cases).There was 1 case of abdominal pain in control group,with the incidence of 2.86％ (1/35 cases,P ＞ 0.05).Conclusion The clinical effect of lanthanum carbonate combined with calcium acetate is great in the treatment of hemodialysis patients with hyperphosphatemia.关键词
碳酸镧/醋酸钙/血液透析/高磷血症Key words
lanthanum carbonat/calcium acetate/hemodialysis/hyperphosphatemia分类
医药卫生引用本文复制引用
叶红英,张婷婷,黄坚..碳酸镧咀嚼片联合醋酸钙片治疗维持性血液透析患者高磷血症的临床研究[J].中国临床药理学杂志,2017,33(16):1531-1533,3.基金项目
浙江省卫生厅科研基金资助项目(2012KYB227) （2012KYB227）
