中国现代医学杂志2017，Vol.27Issue(23)：7-12,6.DOI:10.3969/j.issn.1005-8982.2017.23.002
奈帕芬胺对角膜组织中前列腺素E2的作用研究
Effect of Nepafenac on prostaglandin E2 in corneal tissue
摘要
Abstract
Objective To set up a rabbit model of anterior segment ischemia (ASI) with the method of multi-rectus tenotomy, and to investigate the expression of PGE2 in cornea of the model and the effect of Nepafenac on corneal PGE2. Methods Fifty-four purebred health male Japanese White Rabbits without eye diseases were randomly divided into two groups. There were 18 rabbits (36 eyes) in the control group and 36 rabbits (72 eyes) in the operation group which were futher randomly divided into ischemic group (36 left eyes of the 36 rabbits) and treatment group (36 right eyes of the 36 rabbits). The changes of cornea were observed under slit-lamp in different periods in each group. Then the cornea tissue was taken for pathological and immunohistochemical examinations, the expression of PGE2 in cornea tissue was observed at different time. Results At each time point, the expression of PGE2 in the ischemic group increased ( < 0.05), the expression of PGE2 in the treatment group reduced compared to the ischemia group with statistical significance ( <0.05). Conclusions PGE2 may play an important role during the onset of ASI. Nepafenac can effectively restrain PGE2 in the corneal tissue.关键词
奈帕芬胺/前列腺素E2/角膜/眼前节缺血Key words
Nepafenac/prostaglandin E2/cornea/anterior segment ischemia分类
医药卫生引用本文复制引用
刘岩,张潇,苏杰..奈帕芬胺对角膜组织中前列腺素E2的作用研究[J].中国现代医学杂志,2017,27(23):7-12,6.基金项目
河北省卫计委课题(No:20170198) （No:20170198）
河北省唐山市科技局课题(No:13130292z) （No:13130292z）
华北理工大学教改课题(No:z1516-07) （No:z1516-07）
