中国现代医学杂志2017，Vol.27Issue(23)：52-56,5.DOI:10.3969/j.issn.1005-8982.2017.23.010
睡眠训练对帕金森病非运动症状的改善作用
Sleep training in improvement of non-motor symptoms of Parkinson's disease
摘要
Abstract
Objective To investigate the effect of sleep training on sleep quality, the symptoms of depression and anxiety in patients with Parkinson's disease. Methods Using the method of retrospective analysis and follow-up, 321 cases of Parkinson's disease (PD) diagnosed in Shaanxi Kangfu Hospital between March 2012 and September 2014 were evaluated with Hamilton Depression Scale (HAMD scale), Hamilton Anxiety Scale (HAMA scale) and Alzheimer's Disease Assessment Scale (ADAS-cog). The qualified patients were divided into depression group (group A), anxiety group (group B) and cognitive impairment group (group C) (when a patient had more than two kinds of symptoms meantime, grouping according to the highest score), then the sleeping quality was investigated with "Pittsburgh Sleep Quality Index" (PSQI), and the correlations between non motor symptoms and sleeping quality were analyzed. The sleeping training program was performed in the patients with sleeping disorder for 3-6 months, then PSQI, HAMD, HAMA and ADAS-cog scores were evaluated again. Results Of the 321 PD patients, 255 had non-motor symptoms. In all three groups, sleeping quality and non-motor symptoms were positively correlated ( <0.05). After sleep training, sleeping quality of the groups A and B was significantly improved ( <0.05), and the HAMD and HAMA scores were significantly reduced ( < 0.05). Conclusions Continuous sleep training can effectively improve the sleeping quality of patients with PD, and improve the symptoms of depression and anxiety. However, it has no effect on cognitive impairment.关键词
帕金森病/睡眠质量/认知障碍/抑郁/焦虑Key words
Parkinson's disease/sleeping quality/cognitive impairment/depression/anxiety分类
医药卫生引用本文复制引用
刘利,王涛,刘江静,杨春娟,曹健,赵光辉,陈丽..睡眠训练对帕金森病非运动症状的改善作用[J].中国现代医学杂志,2017,27(23):52-56,5.基金项目
陕西省自然科学基金(No:2016JM8011) （No:2016JM8011）
国家自然科学基金青年项目(No:81100238) （No:81100238）
西安交通大学基本科研项目(No:xjj2015080) （No:xjj2015080）
