中国现代医学杂志2017，Vol.27Issue(23)：106-111,6.DOI:10.3969/j.issn.1005-8982.2017.23.022
89SrCl2联合99mTc-MDP治疗转移性骨癌临床疗效的系统评价
Systematic review of clinical effect of Strontium chloride combined with 99mTc-methylene diphosphonate on metastatic bone cancer in China
田发奎 1季如春 1杨庭显1
作者信息
- 1. 青海大学附属医院 核医学科,青海 西宁 810001
- 折叠
摘要
Abstract
Objective To evaluate the clinical effect of combination therapy with Strontium chloride and 99mTc-methylene diphosphonate on metastatic bone cancer in China. Methods A comprehensive search was performed in CAJD, CNKI (1994-2016), WANFANG (1999-2016), VIP (1989-2016) and CB Mdisc (1994-2016) databases to collect the randomized controlled trials (RCTs) in which combined therapy with Strontium chloride and 99mTc-methylene diphosphonate was applied to metastatic bone cancer in China. Meta-analysis was performed to analyze the RCTs. Results In the 16 RCTs which met the research standards, 1,366 patients were analyzed. The meta-analysis results suggested that, compared with the Strontium chloride group, bone pain, bone metastasis control and life quality were improved significantly in the combination therapy group ( <0.05); and the adverse reactions had no significant differences between the two groups ( >0.05). Conclusions On the basis of symptomatic and supportive treatment, the effect of combined therapy of Strontium chloride and 99mTc-methylene diphosphonate is positive for treatment of metastatic bone cancer, and better than that of simple Strontium chloride treatment.关键词
转移性骨癌/联合治疗/氯化锶/99mTc-亚甲基二膦酸盐/系统评价Key words
metastatic bone cancer/combined therapy/Strontium chloride/99mTc-methylene diphosphonate/systematic review分类
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田发奎,季如春,杨庭显..89SrCl2联合99mTc-MDP治疗转移性骨癌临床疗效的系统评价[J].中国现代医学杂志,2017,27(23):106-111,6.
