中国药房2017，Vol.28Issue(28)：3911-3914,4.DOI:10.6039/j.issn.1001-0408.2017.28.07
猪源纤维蛋白贴对大鼠肝脏及肝素化兔臀大肌创面的止血作用
Study on the Hemostatic Effect of Porcine Fibrin Sealant Patch on Bleeding Wound of Liver in Rats and Gluteus Maximus in Heparinized Rabbits
摘要
Abstract
OBJECTIVE:To study the hemostatic effect of porcine fibrin sealant patch (DBT) on bleeding wound of liver in rats and gluteus maximus in heparinized rabbits. METHODS:48 rats and 24 rabbits were randomly divided into sham operation group,operation control group (gauze hemostasis),medical collagen sponge group and DBT group. Except for sham operation group,animals in other groups were reduced for rat model with liver bleeding or heparinized rabbit model with gluteus maximus bleeding. The hemostatic time was recorded,bleeding amount was calculated;DBT degradation and wound adhesion in liver after 3,13 weeks were observed;re-bleeding rate of heparinized rabbits in medical collagen sponge group and DBT group were investi-gated. RESULTS:Compared with sham operation group,the hemostatic time and bleeding amount of animals in operation control group were significantly increased(P<0.01). Compared with operation control group,the hemostatic time and bleeding amount of animals in DBT group and medical collagen sponge group were significantly reduced (P<0.01). After 3,13 weeks,different de-gree of adhesion appeared in the wound of rats in each group,while the adhesion scores had no statistical significances(P>0.05). After 13 weeks,liver margin of rats in administration groups was slightly blunt,but it basically had been restored to preoperative state,with good healing. DBT can be degraded and absorbed completely. The re-bleeding rate of rabbits in DBT group were33.3%,66.7% in medical collagen sponge group. CONCLU-SIONS:DBT has good hemostatic effect on fragile organs and the body with blood coagulation dysfunction,and can be de-graded and absorbed. Its effect is equivalent to medical colla-gen,while the adhesive strength is slightly better than the latter.关键词
纤维蛋白贴/肝脏出血/臀大肌出血/止血/凝血功能障碍/大鼠/兔Key words
Fibrin sealant patch/Hepatorrhagia/Gluteus maximus bleeding/Hemostasis/Blood coagulation dysfunc-tion/Rats/Rabbits分类
医药卫生引用本文复制引用
李伟达,邓乐君,朱晋辉,陈灶妹,李健,张俊辉,万华印,李茹冰..猪源纤维蛋白贴对大鼠肝脏及肝素化兔臀大肌创面的止血作用[J].中国药房,2017,28(28):3911-3914,4.基金项目
国家科技重大新药创制项目(No.2013ZX09J13110) （No.2013ZX09J13110）
中央军委2016年度军队后勤科研计划项目(No.CGZ16C009) （No.CGZ16C009）
广州市科技计划项目(No.201509010012、201704020173) （No.201509010012、201704020173）
