中国药房2017，Vol.28Issue(28)：3987-3991,5.DOI:10.6039/j.issn.1001-0408.2017.28.27
Box-Behnken响应面法优化水溶性壳聚糖对黄莪凝胶水提液的除杂工艺
Optimization of Clarification Technology of Water-soluble Chitosan on Huang'e Gel Water Extract by Box-Behnken Response Surface Method
王冬东 1张辉靠 1孙程 1吕晓敏 1胡荣1
作者信息
- 1. 扬州大学医学院药学系,江苏扬州 225001
- 折叠
摘要
Abstract
OBJECTIVE:To optimize the technology conditions of water-soluble chitosan on Huang'e gel water extract solu-tion. METHODS:Using the comprehensive scores of transmittance ratio,impurity removal rate,naringin retention rate as indexes, Box-Behnken response surface method was used to optimize the amount of water-soluble chitosan,shocking time and temperature in clarifying technology,and verification test was conducted. RESULTS:The clarification effect was the best when the volume ra-tio of TCM extract solution with proportion ≥1.3 to amount of 0.01 g/mL water-soluble chitosan was 2.2,shocking for 100 min at 70 ℃. In the verification test,the average transmittance ratio was 87.3%,impurity removal rate was 41.5%,and naringin reten-tion rate was 131.38%. The measured values of comprehensive scores were 97.35%,98.92% and 98.04%,showing relative error of -0.87%,0.73% and -0.16% with the predicted values(98.27%),respectively. CONCLUSIONS:The method can effectively optimize the clarification technology parameters of water-soluble chitosan on Huang'e gel water extract solution.关键词
响应面法/水溶性壳聚糖/中药水提液/柚皮苷Key words
Response surface method/Water-soluble chitosan/TCM extract solution/Naringin分类
医药卫生引用本文复制引用
王冬东,张辉靠,孙程,吕晓敏,胡荣..Box-Behnken响应面法优化水溶性壳聚糖对黄莪凝胶水提液的除杂工艺[J].中国药房,2017,28(28):3987-3991,5.
