中国药房2017，Vol.28Issue(28)：3992-3995,4.DOI:10.6039/j.issn.1001-0408.2017.28.28
明胶空心胶囊中7种元素含量测定方法的建立与应用
Establishment and Application of Content Determination Method for 7 Elements in Gelatin Hollow Capsule
摘要
Abstract
OBJECTIVE:To provide reference for improving the quality of Gelatin hollow capsule. METHODS:Atomic fluo-rescence spectrometry was used to determine the contents of Hg,As in Gelatin hollow capsule;graphite furnace atomic absorption spectrometry was used to determine the contents of Cr,Pb,Cd;flame atomic absorption spectrometry was used to determine the contents of Cu,Zn;and the contents of 7 elements in 48 batches of commercially available Gelatin hollow capsule were deter-mined. RESULTS:Each element showed good linear relationship in each mass concentration range(Cr,Pb,Cd,As and Hg were respectively 0-10,0-20,0-1.5,0-10,0-1.0μg/L;Cu and Zn were 0-1.8 mg/L)(r≥0.9969). The detection limits of Cr,Pb,Cd, Cu,Zn,Hg and As were 0.065,0.007,0.011,0.004,0.010,0.108,0.004 μg/L,respectively. RSDs of precision tests were no more than 2.5%(n=6);RSDs of reproducibility tests were no more than 7.5%(n=6);average recoveries ranged in 88.6%-109.5%(RSD≤6.7%,n=6). The contents of 7 elements in the 48 batches of samples were in line with the relevant provi-sions in Chinese Pharmacopoeia(2015 edition,part 4)and pharmacopoeia or standards in other countries or organizations. CON-CLUSIONS:The method shows high sensitivity,high precision with accurate and reliable results,and can be used for the content determination of Cr,Pb,Cd,Cu,Zn,Hg and As in Gelatin hollow capsule. The 48 batches of Gelatin hollow capsule from differ-ent manufacturers have good quality.关键词
明胶空心胶囊/元素/原子荧光光度法/石墨炉原子吸收法/火焰原子吸收法/市售样品Key words
Gelatin hollow capsule/Element/Atomic fluorescence spectrometry/Graphite furnace atomic absorption spectrom-etry/Flame atomic absorption spectrometry/Commercially available samples分类
医药卫生引用本文复制引用
王发英,吴查青..明胶空心胶囊中7种元素含量测定方法的建立与应用[J].中国药房,2017,28(28):3992-3995,4.基金项目
浙江丽水市科技计划项目(No.2010JYZB19) （No.2010JYZB19）
