中成药2017，Vol.39Issue(9)：1766-1770,5.DOI:10.3969/j.issn.1001-1528.2017.09.002
参蛤散对腹主动脉缩窄心力衰竭大鼠心功能的影响
Effects of Shenge Powder on heart function in rats with heart failure by coarctation of abdominal aorta
摘要
Abstract
AIM To investigate the effects of Shenge Powder (Ginseng Radix et Rhizoma,Gecko) on heart function in rats with heart failure by coarctation of abdominal aorta and its mechanism of action.METHODS The heart failure rats were fed with Shenge Powder [1.89 g/(kg · d)] or bisoprolol [1 mg/(kg · d)] for twelve weeks.The pathological morphology,hemodynamics,cardiographic index and effect on protein expression of PGC-1 α in sham operation group,model group,Shenge Powder group and Bisoprolol group were observed.RESULTS Compared with the model group,Shenge Powder increased ejection fraction (EF) (P ＜ 0.05),decreased left ventricular end-diastolic pressure (LVEDP) (P ＜ 0.01),improved maximal rate of left ventricular pressure development (dp/dtmax) and maximal rate of left ventricular pressure decay (dp/dtmin) (P ＜ 0.01),reduced myocardial tissue lesions and myocardial fibrosis.There was no significant difference in PGC-1α protein expression between the Shenge Powder group and the model group.CONCLUSION Shenge Powder can improve left ventricular function in rats with heart failure,and reduce the pathological changes of myocardium tissue.关键词
参蛤散/心力衰竭/PGC-1α/线粒体Key words
Shenge Powder/heart failure/PGC-1αt/mitochondria分类
医药卫生引用本文复制引用
朱灵妍,魏易洪,杨娟,林赟霄,曹敏,王佑华,苑素云,周端..参蛤散对腹主动脉缩窄心力衰竭大鼠心功能的影响[J].中成药,2017,39(9):1766-1770,5.基金项目
国家科技支撑计划(2012BAI41B05) （2012BAI41B05）
国家自然科学基金青年基金(81202660) （81202660）
上海市“杏林新星”计划(ZYSNXD011-RC-XLXX-20130001) （ZYSNXD011-RC-XLXX-20130001）
