金艳 1钦丹萍 2杨新艳 1王耀东 1张春丽 3代群4
作者信息
- 1. 浙江中医药大学第一临床医学院,浙江杭州310053
- 2. 浙江中医药大学附属第一医院消化内科,浙江杭州310006
- 3. 浙江中医药大学附属第一医院病理科,浙江杭州310006
- 4. 浙江中医药大学附属第一医院胃肠研究实验室,浙江杭州310006
- 折叠
摘要
Abstract
AIM To observe the effects of Kelisha Capsules (Angelicae dahuricae Radix,Atractylodis Rhizoma,Acori tatarinowii Rhizoma,etc.) on rats with acetic acid colitis.METHODS Seventy rats were randomly divided into normal group,model group,Montmorillonite Powder group,sulfasalazine (SASP) group,low-,medium-and high-dose of Kelisha Capsules groups.Except for the normal group,10％ acetic acid solution was injected into the anus of rats in another six groups to establish model for ulcerative colitis.After administration for fourteen days,general conditions and status of feces were observed,the levels of serum IL-1β,IL-6,TNF-α and EGF were measured on the 1 st,10th,14th days by ELISA.After the 15th day,the injury to colon mucosa of rats was observed,and damage indexes were evaluated.RESULTS Compared with the model group,the inflammatory condition of colon mucosa in the Kelisha Capsules groups was improved,which was less obvious than that in the SASP group.Compared with the SASP group,the levels of serum IL-1β,IL-6 and TNF-oα in the Kelisha Capsules groups were increased on the 10th,14th days,and the difference between the low-dose group and the SASP group had statistical significance (P ＜ 0.05).Compared with the Montmorillonite Powder group,the level of serum EGF in the Kelisha Capsules groups was decreased on the 10th,14th days,which was higher than that in the SASP group,and the difference between the high-dose group and the SASP group had statistical significance (P ＜ 0.05).CONCLUSION The effect of Kelisha Capsules on rats with acetic acid colitis is better than that of Montmorillonite Powder,but is not as effective as that of SASP.关键词
乙酸性结肠炎/克痢痧胶囊/蒙脱石散/柳氮磺胺吡啶(SASP)/IL-1/IL-6/TNF-α/EGFKey words
acetic acid colitis/Kelisha Capsules/Montmorillonite Powder/salicyzosulfapyridine (SASP)/IL-1 β/IL-6/TNF-α/EGF分类
医药卫生
