中成药2017，Vol.39Issue(9)：1795-1799,5.DOI:10.3969/j.issn.1001-1528.2017.09.007
舒血宁注射液对脓毒症患者Lac、Presepsin和NOS水平的影响
Effects of Shuxuening Injection on Lac, Presepsin and NOS levels in sepsis patients
摘要
Abstract
AIM To investigate the effects of Shuxuening Injection (Ginkgo biloba leaf extract) on serum lactic acid (Lac),soluble CD14-st (Presepsin) and nitric oxide synthase (NOS) levels in sepsis patients.METHODS One hundred and eight patients with sepsis treated by routine treatment in our hospital from Jan.2014 to Oct.2016 were randomly divided into two groups,control group and Shuxuening group (therapy group).Two weeks were one therapeutic course.Before the treatment (the onset of patients within 3 hours),at 6 hours and 5 days after the treatment,Lac and Presepsin levels were detected,and the changes of nitric oxide (NO),NOS,inducible nitric oxide synthase (iNOS) and sequential organ failure assessment (SOFA) score were observed.Incidence of major adverse cardiac events (MACE) and 28-day survival were recorded at the same time.RESULTS Before the treatment,there were no significant differences in SOFA score and the levels of Lac,Presepsin,NO,NOS and iNOS between the two groups (P ＞ 0.05).Six hours after the treatment,the levels of Lac and Presepsin in the therapy group were lower than those in the control group (P ＜ 0.05),both the two groups had lower levels of Lac and Presepsin than those before the treatment (P ＜ 0.05);five days after the treatment,the levels of Lac and Presepsin in the two groups were lower than those at 6 hours after the treatment (P ＜ 0.05),the levels of Lac and Presepsin in the therapy group were lower than those in the control group (P ＜ 0.05).The SOFA score,NO,NOS and iNOS levels after the treatment in the therapy group were lower than those in the control group (P ＜ 0.05).The levels of Lac and Presepsin in sepsis patients were positively correlated with SOFA score (r =0.245,0.261,P =0.011,0.006).The patients in the therapy group had lower incidence of MACE and 28-day mortality rate than those in the control group (P ＜ 0.05).CONCLUSION The therapeutic effect of Shuxuening Injection combined with routine treatment on sepsis patients is superior to that of routine treatment,which can improve the prognosis of patients to a certain extent.关键词
舒血宁注射液/脓毒症/乳酸(Lac)/可溶性CD14亚型(Presepsin)/一氧化氮合酶(NOS)/主要心脏不良事件(MACE)Key words
Shuxuening Injection/sepsis/lactic acid (Lac)/sCD14-st (Presepsin)/nitric oxide synthase (NOS)/major adverse cardiac events (MACE)分类
医药卫生引用本文复制引用
刘亚晶,李春明,亢宏山,王金荣,安立娟,齐洪娜,褚永果..舒血宁注射液对脓毒症患者Lac、Presepsin和NOS水平的影响[J].中成药,2017,39(9):1795-1799,5.基金项目
衡水市科学技术研究与发展计划项目(15019) （15019）
