中国中西医结合杂志2017，Vol.37Issue(9)：1050-1053,4.DOI:10.7661/j.cjim.20170512.153
EGFR-TKI治疗后非小细胞肺癌中医证候研究
Study on Distribution of Traditional Chinese Medicine Syndromes of NSCLC after EGFR-TKI Treatment
摘要
Abstract
Objective To observe the distribution of Chinese Medicine(CM) syndromes in patients with non-small cell lung cancer(NSCLC) after EGFR-TKIs treatment.Methods The clinical materials,including symptoms,signs,and manifestations of tongue and pulse,were investigated in 506 NSCLC patients by using clinical epidemiological method after EGFR-TKIs,and then the characteristics of CM syndromes in NSCLC patients after EGFR-TKIs treatment were explored by cluster analysis.On the basis of the cluster analysis the primary and secondary symptoms of each syndrome were identified preliminarily by factor analysis.Result Fei-yin deficiency syndrome(281 cases,55.53％),qi-yin deficiency syndrome(145 cases,28.66％),Fei-Pi qi deficiency syndrome(80 cases,15.81％) were the main CM syndrome types of NSCLC patients after EGFR-TKIs treatment.The primary syndrome elements of Fei-yin deficiency syndrome were cough,less sputum,sticky sputum,skin rash,itching,dry skin,thirst,red tongue,fissured tongue,thin pulse.Secondary symptoms was thin lingual fur or white lingual fur (P =0.001).Qi-yin deficiency syndrome differentiation basis for dizziness,dry mouth,weak pulse,little sleep.Secondary symptoms were anhelation,hoose,dry pharynx,vexation(P =0.001).The primary syndrome elements of Fei-Pi qi deficiency were lassitude,nausea,anorexia,loose stool,teeth-marked tongue,slippery pulse.Secondary symptoms were sallow complexion or chest tightness (P =0.001).Conclusion The main syndromes of patients with NSCLC after EGFR-TKIs treatment were Fei-yin deficiency syndrome,qi-yin deficiency syndrome,Fei-Pi qi deficiency syndrome,and the core syndrome was Fei-yin deficiency.关键词
表皮生长因子受体激酶酪氨酸阻滞剂/非小细胞肺癌/中医证候/聚类分析/因子分析Key words
sepidermal growth factor receptor tyrosine kinase inhibitors/non-small cell lung cancer/Chinese medicine syndrome/cluster analysis/factor analysis引用本文复制引用
许海柱,孙建立,张璇..EGFR-TKI治疗后非小细胞肺癌中医证候研究[J].中国中西医结合杂志,2017,37(9):1050-1053,4.基金项目
国家自然科学基金委员会资助项目(No.81573890) （No.81573890）
上海市进一步加快中医药事业发展三年行动计划(No.CCCX-3-3001) （No.CCCX-3-3001）
国家中医药管理局中医临床研究基地业务建设科研专项课题(No.JDZX2015069) （No.JDZX2015069）
龙华医院第三批中青年名中医培养计划(No.RC-2017-01-10) （No.RC-2017-01-10）
