中国中西医结合杂志2017，Vol.37Issue(9)：1054-1058,5.DOI:10.7661/j.cjim.20170628.165
中医辨证疗法联合埃克替尼治疗晚期非小细胞肺癌疗效观察
Effect of Chinese Medicine Treatment Based on Syndrome Differentiation Combined with lcotinib In Treating Advanced Non-small Cell Lung Cancer
摘要
Abstract
Objective To observe the effect and adverse reaction of Chinese medicine (CM)treatment based on syndrome differentiation combined with Icotinib in treating advanced non-small cell lung cancer (NSCLC).Methods The clinical trial enrolled 60 patients with advanced NSCLC,who were randomly assigned to the therapy group and the control group,30 in each group.the therapy group was treated with Icotinib combined with CM treatment,the control group only received Icotinib.The treatment lasted until disease progressed or intolerable toxic/adverse reactions accured.The overall response rate,disease control rate,the quality of life(EORTC QLQ-C30,QLQ-LC13),performance status,adverse reactions,and CM syndrome score were analyzed after treatment,and the progression free survival was calculated.Results Compared with the control group,the PFS in the therapy group was prolonged (337 days vs.238 days,P =0.028).The scores of physical function,the total health condition and financial difficulty in the EORIC QLQ-C30 increased after treatment in therapy group (P ＜ 0.05),while the other scores of fatigue,pain,shortness of breath,insomnia,anorexia and diarrhea decreased (P ＜0.05).The scores in shortness of breath,cough and chest pain in the QLQ-LC13 decreased after treatment in therapy group(P ＜0.05).The overall response rate,the disease control rate,the performance status and the adverse reactions were superior in therapy group as compared with those in control group,but there was no statistical difference(P ＞0.05).Conclusion TCM combined with Icotinib could prolong the PFS,improve the quality of life and CM syndrome for patients with NSCLC.关键词
辨证论治/埃克替尼/晚期非小细胞肺癌Key words
treatment based on syndrome differentiation/lcotinib/advanced non-small cell lung cancer引用本文复制引用
吴琼茜,刘苓霜,姜怡,沈丽萍,徐云华..中医辨证疗法联合埃克替尼治疗晚期非小细胞肺癌疗效观察[J].中国中西医结合杂志,2017,37(9):1054-1058,5.基金项目
上海市科学技术委员会科研计划项目(No.13401905100) （No.13401905100）
上海市卫生和计划生育委员会科研课题(No.201440436) （No.201440436）
