中国中西医结合杂志2017，Vol.37Issue(9)：1059-1062,4.DOI:10.7661/j.cjim.20170702.166
晚期结直肠癌患者中医证型、中医体质与生存结局相关性分析
Relationship between Advanced Colorectal Cancer Patients' Chinese Medicine Syndrome, Body Condition and Survival Outcomes
摘要
Abstract
Objective To evaluate the relationship between Chinese Medicine (CM) syndrome,body condition and survival outcomes of advanced colorectal cancer (CRC) patients.Methods This retrospective case-control study was conducted among continuous advanced (stage Ⅳ) CRC patients samples from Professor Yang Yu-fei oncology clinic in Xiyuan Hospital of China Academy of Chinese Medical Sciences.By follow-up and retrospectively screening,the study enrolled 19 stage Ⅳ CRC patients into disadvantage survival group (disadvantage group) according to overall survival time,and 76 stage Ⅳ CRC patients into advantage survival group (advantage group) matched by age,gender and tumor location.The relationship between CM syndromes,body conditions and survival outcome were investigated by Chi-square test and Logistic regression model.Results Among all the patients,the incidence of Gan and Pi disharmony syndrome was significant higher in disadvantage group[53％ (10/19)] than in advantage group [20％(15/79),P =0.004],while the blood stagnation condition was significant higher in advantage group [26％ (20/79)] than in disadvantage group [5％ (1/19),P =0.048],however Yang deficiency condition was significantly less in advantage group [1％ (1/79)] than in disadvantage group [11％ (2/19),P =0.04].Gan and Pi disharmony syndrome and blood stagnation were independently related to disadvantage survival outcomes for advanced CRC patients (P =0.01 and 0.03 respectively).Conclusion CM syndrome and body condition were associated with survival outcomes of advanced CRC patients.关键词
晚期结直肠癌/中医证型/中医体质/生存结局/回顾性研究/病例对照研究Key words
advanced colorectal cancer/Chinese Medicine syndrome/Chinese Medicine body condition/survival outcomes/retrospective study/case-control study引用本文复制引用
孙凌云,张达,郝洁,程豪,易丹辉,杨宇飞..晚期结直肠癌患者中医证型、中医体质与生存结局相关性分析[J].中国中西医结合杂志,2017,37(9):1059-1062,4.基金项目
首都卫生发展科研专项项目(No.2016-1-4171) （No.2016-1-4171）
首都临床特色应用研究项目(No.Z131107002213101) （No.Z131107002213101）
国家留学基金委2015年国家公派建设高水平大学联合博士培养项目(No.201508110221) （No.201508110221）
