中国中西医结合杂志2017，Vol.37Issue(9)：1081-1084,4.DOI:10.7661/j.cjim.20170523.157
益肾除颤汤联合多巴丝肼片治疗帕金森病随机对照研究
Effect of Yishen Chuchan Decoction Combined with Madopar on Parkinson's Disease :A Randomized Controlled Trial
摘要
Abstract
Objective To observe the clinical efficacy of Yishen Chuchan Decoction combined with Madopar on Parkinson's disease.Methods Totally 86 patients with Parkinson's Disease (PD) were randomized into two groups:the treatment group(43 cases) and the control group(43 cases).During two consecutive months,patients in the treatment group received Madopar and Yishen Chuchan Decoction while patients in the control group were given Madopar and placebo orally.The motor dysfunction rating scale for Parkinson's disease(MDRSPD),unified Parkinson's disease rating scale Ⅲ (UPDRS Ⅲ),non-motor symptom scale(NMSS),performance in chronograph movement (times of left and right hand movement in one minute) and non-motor symptom questionnaire(NMSQuest) were reviewed at three time points:before treatment,treatment for 1 month and treatment for 2 months.The safety parameters of the two groups were also observed after treatment.Results MDRSPD scores and UPDRS scores of both groups decreased after 2 months treatment compared with those before treatment (P ＜0.05,P ＜0.01).Meanwhile,the frequency of chronograph movement of left or right hand increased (P ＜0.05,P ＜0.01).In treatment group,NMSS scores and NMSQuest scores decreased after 1 and 2 months compared with those before treatment (P ＜0.05,P ＜0.01).Compared with control group,the UPDRS scores decreased and the frequency of chronograph movement increased in treatment group after 2 months (P ＜0.05).The NMSS scores and NMSQuest scores decreased after 1 and 2 months in treatment group compared with control group (P ＜ 0.05,P ＜ 0.01).Conclusion Yishen Chuchan Decoction combined with Madopar could improve the symptoms of Parkinson's disease.关键词
帕金森病/益肾除颤汤/多巴丝肼片/帕金森病运动功能评定量表/非运动症状评价量表Key words
Parkinson's disease/Yingshen Chuchan Decoction/Madopar/motor dysfunction rating scale for Parkinson's disease/Non-motor symptom scale引用本文复制引用
杨宁,宁厚旭,过伟峰,刘卫国,乔飞..益肾除颤汤联合多巴丝肼片治疗帕金森病随机对照研究[J].中国中西医结合杂志,2017,37(9):1081-1084,4.基金项目
江苏省中医药局科技项目(No.LB09088) （No.LB09088）
