中国中西医结合杂志2017，Vol.37Issue(9)：1100-1104,5.DOI:10.7661/j.cjim.20170704.178
银杏叶提取物预处理对2型糖尿病大鼠心肌梗死后心血管保护效应研究
Cardiovascular Protection Mechanism of Extract of Ginkgo Biloba on the Rat Model of Type 2 Diabetes after Myocardial Infarction
摘要
Abstract
Objective To observe the effect and mechanism of extract of Ginkgo biloba (EGb) on cardiovascular protection on the rat model of type 2 diabetes (T2DM) after myocardial infarction.Methods T2DM rat model was established by intraperitoneal injection of streptozotocin (35 mg/kg) combined with high fat diet,and the model rats were randomly divided into the model group (equivalent distilled water),the sham group (equivalent distilled water),the metformin group (100 mg · kg-1 · d-1),the low dose of EGb group (200 mg · kg-1 · d-1) and the high dose of EGb group (400 mg · kg-1 · d-1),12 in each group.The myocardial infarction rat model was established by ligating the anterior descending branch of coronary artery after T2DM rats were administered with EGb for 4 weeks continuously.Besides,another 10 rats were recruited as a normal group.The levels of fasting blood glucose (FBG),fasting serum insulin (FINS),insulin resistance index (IRI) and insulin sensitive index (ISI),TG,TC,HDL-C and LDL-C,plasma P-selectin,CK-MB and cTnl,TNF-α,IL-1 and IL-6,gelsolin,F-actin and vitamin D binding protein (DBP) were observed.Results Compared with the normal group,FBG,FINS,IRI,TG,TC,LDL-C,CK-MB,CTnl,IL-6,TNF-α,IL-1,P-selectin,gelsolin(PRP),F-actin increased(P ＜0.01,P ＜0.05),ISI,HDL-C,gelsolin(PPP),DBP decreased in each medicated group(P ＜0.01,P ＜0.05).Compared with the model group,FBG,FINS,IRI,TG,TC,LDL-C,CK-MB,CTnl,IL-6,TNF-α,IL-1,P-selectin decreased (P ＜0.01,P ＜0.05),ISI,HDL-C increased in the EGb group and metformin group(P ＜0.01,P ＜0.05);gelsolin(PRP),F-actin decresed(P ＜0.05),gelsolin(PPP),DBP increased in the two EGb treated group (P ＜0.05).Conclusions EGb could reduce blood glucose,regulate lipid metabolism,anti-inflammatory and improve insulin resistance.EGb pretreatment could relieve myocardial injury caused by acute myocardial ischemia,and its cardiovascular protective effect may be related to activation of actinscavenger system.关键词
银杏叶提取物/2型糖尿病/心肌梗死/肌动蛋白清除系统Key words
extract of Ginkgo biloba/type 2 diabetes/myocardial infarction/actinscavenger system引用本文复制引用
刘玥,刘艳飞,田晋帆,付长庚,陈可冀..银杏叶提取物预处理对2型糖尿病大鼠心肌梗死后心血管保护效应研究[J].中国中西医结合杂志,2017,37(9):1100-1104,5.基金项目
北京市科技新星计划资助项目(No.Z171100001117027) （No.Z171100001117027）
北京市优秀博士学位论文指导教师科技项目(No.20138450201) （No.20138450201）
