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初均速法预测不同包装金银花药材的有效期

韩赟 谷巍 沈夕坤 巢建国 刘青芝 桑晓华 蒋玲

中药材2017,Vol.40Issue(4):816-822,7.
中药材2017,Vol.40Issue(4):816-822,7.DOI:10.13863/j.issn1001-4454.2017.04.014

初均速法预测不同包装金银花药材的有效期

Stable Life Prediction for Honeysuckle Under Different Packaging Conditions by Initial Average Rate Stability Test

韩赟 1谷巍 2沈夕坤 1巢建国 2刘青芝 1桑晓华 1蒋玲1

作者信息

  • 1. 南京中医药大学药学院,南京江苏210023
  • 2. 苏州市中医医院药学部,苏州江苏213005
  • 折叠

摘要

Abstract

Objective:To study the influence of temperature and humidity on the stability of honeysuckle by initial average rate stability test,to predict the effective period of honeysuckle under different packaging conditions,and to explore the best packaging and storage conditions of honeysuckle.Methods:Measure the content of chlorogenic acid in honeysuckle under ten kinds of commonly used packaging by the temperature and humidity accelerated test.Analyze the degradation kinetics parameters of honeysuckle and predict the effective period of the sample by initial average rate stability test.The reliability of the results was judged by the retention test.Results:The linear relationships between lnv0i,1/T and Hr were good.The term of validity of each sample under normal temperature and humidity was predicted as follows:brown glass bottle,4.17 years,and transparent glass,4.01 years;15 wire transparent polyethylene plastic film bag,3.62 years,10 wire,1.52 years,and 6 wire,0.84 years;transparent plastic bottle,3.67 years;white plastic woven bag,0.86 years;woven bag with 10 wire plastic film bag,2.82 years,and with 6 wire plastic film bag,1.39 years;no packaging,0.46 years.The results of the retention tests were basically consistent with the predicted results by initial average rate stability test.Conclusion:The initial average rate stability test can be applied to predict stable life of honeysuckle under muhiple factors interaction.A large number of the storage of honeysuckle should choose thick plastic bags or plastic bag with woven bags,while daily storage should choose brown glass bottles.It should be stored in a cool and dry place,in order to ensure its quality.

关键词

初均速法/金银花/包装/贮藏/有效期

Key words

Initial average rate stability test/Lonicera japonica Thunb./Package/Storage/Stable life

分类

医药卫生

引用本文复制引用

韩赟,谷巍,沈夕坤,巢建国,刘青芝,桑晓华,蒋玲..初均速法预测不同包装金银花药材的有效期[J].中药材,2017,40(4):816-822,7.

基金项目

江苏省中药优势学科Ⅱ期建设(ysxk-2014) (ysxk-2014)

江苏省中药资源产业化过程协同创新中心项目(ZDXMHT-1-5,ZDXM-3-24) (ZDXMHT-1-5,ZDXM-3-24)

中药材

OA北大核心CSTPCD

1001-4454

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