动物营养学报2017，Vol.29Issue(10)：3467-3471,5.DOI:10.3969/j.issn.1006-267x.2017.10.006
成纤维细胞生长因子23在骨矿物质代谢中的作用及其调控机理
Fibroblast Growth Factor?23: Functions in Bone Mineral Metabolism and Regulation Mechanism
摘要
Abstract
fibroblast growth factor?23 ( FGF23 ) as a bone?derived hormone plays an important role in bone mineral metabolism by mediating the negative feedback loops formed by parathyroid gland, kidney, bone and vitamin D to constructing a bone?kidney?parathyroid gland endocrine axis. The secretion, activity and intracel?lular processes of FGF23 are regulated by calcium, phosphate, iron, vitamin D, parathyroid hormone ( PTH) , fibroblast growth factor receptor ( FGFR)/FGF and posttranslational modifications. With the increase of study on FGF23, the researchers have explored new therapeutic interventions on bone mineral metabolism disorder. In order to provide reference for relevant research, functions and regulation mechanism of FGF23 in bone min?eral metabolism were reviewed in this paper.关键词
成纤维细胞生长因子23/骨矿物质代谢/钙/磷/铁Key words
fibroblast growth factor⁃23/bone mineral metabolism/calcium/phosphate/iron分类
农业科技引用本文复制引用
董中亮,任晓曼,卜舒扬,闪爱婷,王玉婷,杨建成..成纤维细胞生长因子23在骨矿物质代谢中的作用及其调控机理[J].动物营养学报,2017,29(10):3467-3471,5.基金项目
国家自然科学基金(31672510) （31672510）
