动物营养学报2017，Vol.29Issue(10)：3773-3780,8.DOI:10.3969/j.issn.1006⁃267x.2017.10.040
胍基乙酸对保育猪生长性能、抗氧化能力和糖代谢关键酶的影响
Effects of Guanidine Acetic Acid on Growth Performance, Antioxidant Capacity and Glycometabolism Key Enzymes of Nursery Pigs
摘要
Abstract
This experiment was conducted to investigate the effects of guanidine acetic acid on growth perform?ance, antioxidant capacity and glycometabolism key enzymes of nursery pigs. Sixty four healthy "Duroc × Landrace×Yorkshire" hybrid piglets with body weight of (19.03±1.30) kg were randomly divided into two groups with four replicates per group and eight piglets per replicate. The piglets in control group were fed a bas?al diet, while the others in guanidine acetic acid group were fed the basal diet supplemented with 600 mg/kg guanidine acetic acid. The pretest lasted for 7 days, and the experiment lasted for 14 days. The results showed as follows:1) compared with control group, average daily gain of nursery pigs in guanidine acetic acid group was significantly increased (P<0.05), and the ratio of feed to gain was significantly decreased (P<0.05). There were no significant differences in final body weight and average daily feed intake between two groups ( P>0.05) . 2) The superoxide dismutase ( SOD) inhibition rate, glutathione ( GSH) content and total antioxi?dant capacity ( T?AOC) in plasma of nursery pigs in guanidine acetic acid group were significantly higher than those in control group ( P<0. 05 ) . There was no significant difference in the content of malondialdehyde (MDA) between two groups (P>0.05). 3) The activities of fructose?6?phosphate kinase (PFK), pyruvate kinase ( PK) , isocitrate dehydrogenase ( IDH) , malate dehydrogenase ( MDH) , nicotinamide adenine dinu?cleotide coenzyme Q reductase ( NADH?CoQ) and creatine kinase ( CK) in plasma of nursery pigs in guani?dine acetic acid group were significantly higher than those in control group ( P<0.01) . Compared with control group, the activity of hexokinase (HK) in plasma in guanidine acetic acid group had a decrease trend (0.05≤P<0.10) , and the activity of adenosine triphosphate ( ATP) synthase ( ATPase) in plasma in guanidine acetic acid group had an increase trend (0.05≤P<0.10). In conclusion, dietary guanidine acetic acid can improve the growth performance and antioxidant capacity, promote catabolism in vivo by increasing the activities of gly?cometabolism key enzymes ( PFK, PK, IDH, MDH ) and mitochondrial respiratory chain related enzymes ( NADH?CoQ, ATPase) , improve the body ATP level, and thus may promote the energy storage organiza?tions (muscle and fat) synthesis.关键词
胍基乙酸/保育猪/生长性能/抗氧化能力/糖代谢Key words
guanidine acetic acid/nursery pigs/growth performance/antioxidant capacity/glycometabolism分类
农业科技引用本文复制引用
李洁蕾,郝月,顾宪红..胍基乙酸对保育猪生长性能、抗氧化能力和糖代谢关键酶的影响[J].动物营养学报,2017,29(10):3773-3780,8.基金项目
国家重点研发计划(2016YFD0500501) （2016YFD0500501）
国家重点基础研究发展计划课题(2012CB124706) （2012CB124706）
中国农业科学院科技创新工程资助( ASTIP?IAS07) （ ASTIP?IAS07）
